Anovadiya Ashish P, Barvaliya Manish J, Patel Tejas K, Tripathi C B
Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India.
J Pharmacol Pharmacother. 2011 Jul;2(3):187-8. doi: 10.4103/0976-500X.83285.
Seven years old male child (24 kg weight) diagnosed as a case of sub acute appendicitis treated with ciprofloxacin, immediately developed multiple erythmatous papules. Reaction subsided after withholding ciprofloxacin and treatment with dexamethasone and chlorpheneramine maleate. It was developed again when treated with levofloxacin and subsided after withdrawal. IgE binding at 7(th) position of core structure of fluoroquinolones likely to be the mechanism. As all the fluoroquinolones have similar core structure, hypersensitivity to one may have cross sensitivity to other fluoroquinolones. It is advisable to avoid other fluoroquinolones and switch over to other group of antibiotics when hypersensitivity to one occurs.
一名7岁男童（体重24千克）被诊断为亚急性阑尾炎，接受环丙沙星治疗后，立即出现多处红斑丘疹。停用环丙沙星并用地塞米松和马来酸氯苯那敏治疗后，反应消退。使用左氧氟沙星治疗时再次出现，停药后消退。氟喹诺酮类药物核心结构第7位的IgE结合可能是其机制。由于所有氟喹诺酮类药物都有相似的核心结构，对一种药物过敏可能对其他氟喹诺酮类药物有交叉过敏反应。当对一种药物过敏时，建议避免使用其他氟喹诺酮类药物，改用其他抗生素组。
