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乳糜泻与肌内膜增殖:一种可能的关联?

Celiac disease and myointimal proliferation: a possible correlation?

作者信息

Merra Giuseppe, Lago Antonio Dal, Roccarina Davide, Gasbarrini Giovanni, Gasbarrini Antonio, Ghirlanda Giovanni

机构信息

Department of Internal Medicine, Catholic University of Sacred Heart, 'Agostino Gemelli' General Hospital, Rome, Italy.

出版信息

Case Rep Gastroenterol. 2008 Sep;2(3):398-404. doi: 10.1159/000163522. Epub 2008 Nov 14.

Abstract

Celiac disease (CD) is an autoimmune disorder of the small bowel that occurs in genetically predisposed people of all ages, from middle infancy, and is caused by a reaction to gliadin, a gluten protein. Some patients are diagnosed with symptoms related to the decreased absorption of nutrients or with various symptoms which, although statistically linked, have no clear relationship with the malfunctioning bowel. Classic symptoms of CD include diarrhea, weight loss, and fatigue; bowel symptoms may be limited or even absent. In this article we describe the case of a young woman with CD who presents with myointimal proliferation. However multiple cases of vessel thrombosis have been reported in patients with CD. Despite the fact that no definitive relationship between these diseases could be explained, we think this association must be remembered especially in cases of young and tenuous women with these vascular abnormalities.

摘要

乳糜泻(CD)是一种小肠自身免疫性疾病,发生于所有年龄段具有遗传易感性的人群,从幼儿期开始,由对麸质蛋白麦醇溶蛋白的反应引起。一些患者因营养吸收减少相关症状或各种虽有统计学关联但与肠道功能障碍无明确关系的症状而被诊断。CD的典型症状包括腹泻、体重减轻和疲劳;肠道症状可能有限甚至没有。在本文中,我们描述了一名患有CD并伴有肌内膜增生的年轻女性病例。然而,已有报道称CD患者出现多例血管血栓形成。尽管无法解释这些疾病之间的确切关系,但我们认为这种关联必须牢记,尤其是在患有这些血管异常的年轻体弱女性病例中。

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