Imanishi Hisayoshi, Tsuruta Daisuke, Kobayashi Hiromi, Ishii Masamitsu, Nakagawa Koichi
Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Case Rep Dermatol. 2011 Jan;3(1):1-4. doi: 10.1159/000323663. Epub 2011 Jan 7.
Ashy dermatosis is a typically asymptomatic disease of unknown origin that causes symmetrical gray spots to appear on the trunk and extremities. We report 2 cases of ashy dermatosis with unilateral distribution. To our knowledge, only 5 cases of ashy dermatosis with unilateral lesion have been reported so far. Case 1: an 11-year-old woman presented with asymptomatic slate-gray pigmented plaques on the left trunk and left upper arm. The skin biopsy specimen demonstrated a mild lymphohistiocytotic infiltrate in the upper dermis with epidermal and dermal melanosis. Q-Switched ruby laser did not improve such lesions. Case 2: a 21-year-old man was referred to our hospital because of asymptomatic slate-gray pigmented plaques on the left trunk and left upper arm. Histopathological findings were compatible with a mild lymphocytic infiltration with melanin incontinence in the upper dermis. The mechanism that governs unilateral distribution of ashy dermatosis, including in our cases, remains unclear.
灰皮病是一种病因不明的典型无症状疾病，可导致躯干和四肢出现对称性灰色斑点。我们报告2例单侧分布的灰皮病。据我们所知，迄今为止仅报告了5例单侧病变的灰皮病。病例1：一名11岁女性，左侧躯干和左上臂出现无症状的石板灰色色素沉着斑。皮肤活检标本显示真皮上层有轻度淋巴细胞组织细胞浸润，并伴有表皮和真皮黑素沉着。调Q红宝石激光治疗未能改善此类病变。病例2：一名21岁男性因左侧躯干和左上臂出现无症状的石板灰色色素沉着斑转诊至我院。组织病理学检查结果显示真皮上层有轻度淋巴细胞浸润并伴有黑素失禁。包括我们病例在内的灰皮病单侧分布的机制仍不清楚。
