Hoeritzauer Anne Ingrid, Venkatraman Laskshmi, Manus Kieran Mc, Kettle Paul, Sah Shatrugan, Elborn Stuart
Centre for Infection and Immunity, Queens University Belfast, City Hospital, Belfast, BT97AB, UK.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.03.2009.1716. Epub 2009 Sep 7.
A 58-year-old woman was referred from her general practitioner to the respiratory clinic with a 2 year history of recurrent pulmonary infections, mucus hypersecretion and right lobe consolidation following a severe pneumonic illness in 2006. She had no significant risk factors for respiratory disease. Chest computed tomography showed an air bronchogram and right lower lobe consolidation. On initial routine investigation IgA and IgG were normal; however, a discrete IgM paraprotein band in the mid gamma region was seen on serum electrophoresis. She was referred for haematological investigations. Bone marrow biopsy was positive for monoclonal lymphoplasmocytoid B cells and the patient was diagnosed with Waldenström's macroglobulinaemia. Due to recurrent infections and an unclear diagnosis of the lung process, a right lower lobectomy and wedge resection of the middle lobe was performed. This showed bronchial associated lymphoid tissue lymphoma arising in the marginal zone. She has been well since surgery with no further respiratory infections.
一名58岁女性由其全科医生转诊至呼吸科门诊,自2006年患严重肺炎后,有2年复发性肺部感染、黏液分泌过多及右叶实变病史。她无显著的呼吸系统疾病危险因素。胸部计算机断层扫描显示空气支气管征及右下叶实变。初步常规检查显示IgA和IgG正常;然而,血清电泳显示γ区中部有一条离散的IgM副蛋白带。她被转诊进行血液学检查。骨髓活检显示单克隆淋巴浆细胞样B细胞阳性,患者被诊断为华氏巨球蛋白血症。由于反复感染及肺部病变诊断不明,遂行右下叶切除术及中叶楔形切除术。结果显示为边缘区发生的支气管相关淋巴组织淋巴瘤。自手术以来她情况良好,未再发生呼吸系统感染。