Altunhan Hüseyin, Keser Melike, Pekcan Sevgi, Ural Onur, Ors Rahmi
Neonatology, Meram Medical Faculty, Selcuk University, Meram-Konya, Konya, 42080, Turkey.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.05.2009.1894. Epub 2009 Sep 7.
Genital tuberculosis is a major cause of infertility in countries where tuberculosis is endemic. With recent advances in assisted reproductive technology, women with tuberculous endometritis may become pregnant and ultimately have children with congenital tuberculosis. In vitro fertilisation represents a useful treatment for infertility. Congenital tuberculosis is a rare and severe, rapidly progressive, disease. Making an early diagnosis of congenital tuberculosis is difficult, because it can mimic many neonatal illnesses. To the best of our knowledge, we report the first cases of premature twins with congenital tuberculosis following in vitro fertilisation. After the diagnosis of genital tuberculosis in the mother, the twins were screened and diagnosed for tuberculosis. The twins dramatically improved after anti-tuberculosis therapy. We also wish to draw attention to the importance of searching for genital tuberculosis as the possible cause of congenital infection, even if the mother is asymptomatic.
在结核病流行的国家，生殖器结核是导致不孕的主要原因。随着辅助生殖技术的最新进展，患有结核性子宫内膜炎的女性可能会怀孕，并最终生下患有先天性结核病的孩子。体外受精是治疗不孕症的一种有效方法。先天性结核病是一种罕见、严重且进展迅速的疾病。早期诊断先天性结核病很困难，因为它可能与许多新生儿疾病相似。据我们所知，我们报告了首例体外受精后早产双胞胎患先天性结核病的病例。母亲被诊断出生殖器结核后，对双胞胎进行了结核病筛查和诊断。抗结核治疗后，双胞胎病情显著改善。我们还希望提请注意，即使母亲没有症状，也应重视寻找生殖器结核作为先天性感染可能病因的重要性。
