Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Biomed Microdevices. 2012 Feb;14(1):55-65. doi: 10.1007/s10544-011-9585-8.
This paper reports the feasibility of biopsy needle tract cauterization and cauterization monitoring using an embedded array of piezoceramic microheaters. Circular heaters of lead zirconate titanate (PZT-5A), with 200 μm diameter and 70-80 μm thickness, are fabricated using a batch mode micro ultrasonic machining process. These are then assembled into cavities in the walls of 20-gauge stainless steel needles and sealed with epoxy. Experiments are performed by inserting the proposed biopsy needle into porcine tissue samples. The needle surface exceeds the minimum target temperature rise of 33°C for either radial or thickness mode vibrations. The corresponding input power levels are 236 mW and 325 mW, respectively. The tissue cauterization extends 1-1.25 mm beyond the perimeter of the needle and is uniform in all directions. After cauterization, the fundamental anti-resonance frequency and the corresponding impedance magnitude of the PZT heater decrease by 4.1% and 42.6%, respectively, thereby providing a method to monitor the extent of tissue cauterization. A sensing interface circuit capable of measuring the resonance frequency shift of the PZT elements is built and tested using discrete integrated circuit components. The circuit detects the resonance frequency shift from 8.22 MHz to 7.96 MHz of the PZT elements when the biopsy needle is inserted into wax medium. An interface circuit for actuation of the PZT elements for tissue cauterization is also described.
本文报告了使用嵌入式压电陶瓷微加热器阵列对活检针道进行烧灼和监测的可行性。采用批处理微超声加工工艺制造了直径为 200μm、厚度为 70-80μm 的锆钛酸铅(PZT-5A)圆形加热器。然后将这些加热器组装到 20 号不锈钢针壁的腔室中,并使用环氧树脂密封。通过将提出的活检针插入猪组织样本中进行实验。无论是径向还是厚度模式振动,针表面的温升都超过了 33°C 的最小目标温升。相应的输入功率水平分别为 236mW 和 325mW。组织烧灼的范围超出了针的周长 1-1.25mm,并且在各个方向上都是均匀的。烧灼后,PZT 加热器的基频反共振频率和相应的阻抗幅度分别降低了 4.1%和 42.6%,从而提供了一种监测组织烧灼程度的方法。构建并使用离散集成电路元件测试了一种能够测量 PZT 元件的谐振频率偏移的传感接口电路。当活检针插入蜡质介质中时,该电路检测到 PZT 元件的谐振频率从 8.22MHz 到 7.96MHz 的偏移。还描述了用于组织烧灼的 PZT 元件的驱动接口电路。