去氨加压素治疗夜间尿频的疗效和安全性：双盲试验的系统评价和荟萃分析。
Efficacy and safety of desmopressin for treatment of nocturia: a systematic review and meta-analysis of double-blinded trials.
机构信息
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gong Ti Nan Road (or Beijing Worker Stadium South Road), Chao Yang District, Beijing 100020, China.
出版信息
Int Urol Nephrol. 2012 Apr;44(2):377-84. doi: 10.1007/s11255-011-0054-3. Epub 2011 Sep 7.
PURPOSE
The purpose of this analysis was to evaluate the efficacy and safety of desmopressin for the treatment of nocturia.
METHODS
Databases including MEDLINE, EMBASE, ISI web of knowledge, the Cochrane Controlled Trial Register of Controlled Trials and Chinese Biological Medical Database were searched to identify randomized controlled trials (RCTs) that referred to the efficacy and safety of desmopressin for the treatment of nocturia. A systematic review and meta-analysis were conducted.
RESULTS
Five studies involving 619 participants were included for the meta-analysis, and 8 RCTs of cross-over design were also identified for the systematic review. The analysis revealed that desmopressin might significantly decrease the frequency of nocturnal voids, nocturnal urine volume and nocturnal diuresis, potentially resulting in an extended duration of the first sleep period and improved sleep quality. The adverse effects of desmopressin were similar to those observed in the placebo group.
CONCLUSIONS
Administered desmopressin was an effective and well-tolerated treatment for nocturia.
目的
本分析旨在评估去氨加压素治疗夜间尿频的疗效和安全性。
方法
检索 MEDLINE、EMBASE、ISI 网络知识、Cochrane 对照试验注册中心对照试验和中国生物医学文献数据库，以确定涉及去氨加压素治疗夜间尿频疗效和安全性的随机对照试验（RCT）。进行系统评价和荟萃分析。
结果
纳入了 5 项涉及 619 名参与者的研究进行荟萃分析，并确定了 8 项交叉设计的 RCT 进行系统评价。分析结果表明，去氨加压素可能显著减少夜间排尿次数、夜间尿量和夜间尿量，从而延长首次睡眠时间和改善睡眠质量。去氨加压素的不良反应与安慰剂组相似。
结论
去氨加压素是治疗夜间尿频的一种有效且耐受良好的治疗方法。
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