Division of Hematology and Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
J Cell Biochem. 2012 Jan;113(1):3-12. doi: 10.1002/jcb.23335.
All aspects of cellular biology affect the process of regulated cell death, or apoptosis, and disruption of this process is a causative event in many diseases. Therefore, a comprehensive understanding of all pathways that regulate apoptosis would increase our knowledge of basic cellular functions, as well as the etiologies of many diseases. In turn, we may be able to use this knowledge to better treat patients with diseases, including cancer. Although the basic signaling pathway that regulates apoptosis has been known for over 10 years, we still have much to learn about the upstream signaling components that can directly regulate the core apoptosis machinery. The focus of this review will be to direct attention to non-canonical regulators of the BCL2-family of proteins, especially our void of understanding of such interactions, and the controversy that surrounds some such interactions.
细胞生物学的各个方面都会影响细胞程序性死亡（凋亡）的过程，而该过程的紊乱是许多疾病的致病因素。因此，全面了解所有调控凋亡的途径不仅能增进我们对基本细胞功能的认识，也有助于了解许多疾病的病因。反过来，我们也许可以利用这些知识更好地治疗包括癌症在内的各种疾病患者。尽管调控凋亡的基本信号通路已为人所知十余年，但对于能够直接调控核心凋亡机制的上游信号成分，我们仍有许多需要学习的地方。本篇综述的重点是关注 BCL2 蛋白家族的非经典调控因子，特别是我们对这些相互作用缺乏了解的地方，以及一些相互作用存在争议的地方。
