衰老——发育与疾病中的 RNA
Aging--RNA in development and disease.
机构信息
Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
出版信息
Wiley Interdiscip Rev RNA. 2012 Jan-Feb;3(1):133-43. doi: 10.1002/wrna.109. Epub 2011 Sep 6.
Abstract
Given that RNA is involved in virtually all biological processes, it is perhaps not surprising that several RNA-binding proteins are associated with aging and with different age-related disorders. Other articles in this volume will discuss some specific examples of diseases where RNA plays a role that are also associated with aging, such as cancer and inflammation, so here I will discuss some general aspects of how RNA changes with the aging process. I will also discuss some specific examples of RNA-binding proteins that are associated with age-dependent neurological diseases as these provide an interesting framework to examine how lifetime mutations might lead to a late onset disease, although the answers to these questions are still not well understood.
摘要
鉴于 RNA 几乎参与所有的生物过程，几种 RNA 结合蛋白与衰老和不同的与年龄相关的疾病有关，这也许并不奇怪。本卷中的其他文章将讨论 RNA 在某些与衰老相关的疾病中发挥作用的具体例子，如癌症和炎症，因此，我将在这里讨论 RNA 随衰老过程变化的一些一般方面。我还将讨论一些与年龄相关的神经退行性疾病相关的 RNA 结合蛋白的具体例子，因为这些例子为研究终生突变如何导致迟发性疾病提供了一个有趣的框架，尽管这些问题的答案仍未得到很好的理解。
相似文献
1
Aging--RNA in development and disease.衰老——发育与疾病中的 RNA
Wiley Interdiscip Rev RNA. 2012 Jan-Feb;3(1):133-43. doi: 10.1002/wrna.109. Epub 2011 Sep 6.
2
Regulation of DNA damage response by RNA/DNA-binding proteins: Implications for neurological disorders and aging.RNA/DNA结合蛋白对DNA损伤反应的调控：对神经疾病和衰老的影响
Ageing Res Rev. 2024 Sep;100:102413. doi: 10.1016/j.arr.2024.102413. Epub 2024 Jul 19.
3
Disruption of RNA-binding proteins in neurological disorders.神经疾病中RNA结合蛋白的破坏。
Exp Neurol. 2025 Mar;385:115119. doi: 10.1016/j.expneurol.2024.115119. Epub 2024 Dec 19.
4
Towards understanding RNA-mediated neurological disorders.探讨 RNA 介导的神经疾病。
J Genet Genomics. 2014 Sep 20;41(9):473-84. doi: 10.1016/j.jgg.2014.08.003. Epub 2014 Aug 23.
5
Between destiny and disease: genetics and molecular pathways of human central nervous system aging.在命运与疾病之间：人类中枢神经系统衰老的遗传学和分子途径。
Prog Neurobiol. 2011 Feb;93(2):165-81. doi: 10.1016/j.pneurobio.2010.11.006. Epub 2010 Dec 2.
6
RNA-protein interactions in unstable microsatellite diseases.不稳定微卫星疾病中的RNA-蛋白质相互作用
Brain Res. 2014 Oct 10;1584:3-14. doi: 10.1016/j.brainres.2014.03.039. Epub 2014 Apr 4.
7
RNA toxicity and foci formation in microsatellite expansion diseases.微卫星扩张疾病中的RNA毒性与病灶形成
Curr Opin Genet Dev. 2017 Jun;44:17-29. doi: 10.1016/j.gde.2017.01.005. Epub 2017 Feb 14.
8
RNA processing in neurological tissue: development, aging and disease.神经组织中的 RNA 加工：发育、衰老和疾病。
Semin Cell Dev Biol. 2021 Jun;114:57-67. doi: 10.1016/j.semcdb.2020.09.004. Epub 2020 Oct 16.
9
ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases.ELAV/Hu RNA结合蛋白家族：神经疾病、癌症及其他疾病中的关键调节因子。
RNA Biol. 2025 Dec;22(1):1-11. doi: 10.1080/15476286.2025.2471133. Epub 2025 Mar 20.
10
Mitochondrial genetics: a paradigm for aging and degenerative diseases?线粒体遗传学：衰老和退行性疾病的范例？
Science. 1992 May 1;256(5057):628-32. doi: 10.1126/science.1533953.
引用本文的文献
1
Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues.单细胞和组织中原位RNA-蛋白质相互作用与转录组的联合分析
Nat Methods. 2025 Aug 11. doi: 10.1038/s41592-025-02774-4.
2
Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization.维生素D信号在心血管疾病中的作用：巨噬细胞极化的核心地位
Front Cardiovasc Med. 2024 Jun 25;11:1388025. doi: 10.3389/fcvm.2024.1388025. eCollection 2024.
3
Nuclear mRNA Export and Aging.核 mRNA 输出与衰老。
Int J Mol Sci. 2022 May 13;23(10):5451. doi: 10.3390/ijms23105451.
4
Effects of Mindfulness-Based Cognitive Therapy on Peripheral Markers of Stress and Inflammation in Older-Adults With Depression and Anxiety: A Parallel Analysis of a Randomized Controlled Trial.基于正念的认知疗法对伴有抑郁和焦虑的老年人应激与炎症外周标志物的影响：一项随机对照试验的平行分析
Front Psychiatry. 2021 Dec 24;12:804269. doi: 10.3389/fpsyt.2021.804269. eCollection 2021.
5
Ultrastructural immunocytochemistry shows impairment of RNA pathways in skeletal muscle nuclei of old mice: A link to sarcopenia?超微结构免疫细胞化学显示老年小鼠骨骼肌核中 RNA 途径受损：与肌肉减少症有关？
Eur J Histochem. 2021 Mar 24;65(2):3229. doi: 10.4081/ejh.2021.3229.
6
Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans.通过 P 体介导的 eIF4E 可用性调节来维持蛋白稳态，从而延缓秀丽隐杆线虫的衰老。
Cell Rep. 2018 Oct 2;25(1):199-211.e6. doi: 10.1016/j.celrep.2018.09.009.
7
CircularRNA_104670 plays a critical role in intervertebral disc degeneration by functioning as a ceRNA.环状 RNA_104670 通过作为 ceRNA 发挥关键作用，导致椎间盘退变。
Exp Mol Med. 2018 Aug 6;50(8):1-12. doi: 10.1038/s12276-018-0125-y.
8
SUMO1-conjugation is altered during normal aging but not by increased amyloid burden.SUMO1 缀合在正常衰老过程中发生改变，但不会因淀粉样蛋白负担增加而改变。
Aging Cell. 2018 Aug;17(4):e12760. doi: 10.1111/acel.12760. Epub 2018 Apr 6.
9
Expression profiling and functional annotation of noncoding genes across 11 distinct organs in rat development.在大鼠发育的 11 个不同器官中进行非编码基因的表达谱分析和功能注释。
Sci Rep. 2016 Dec 9;6:38575. doi: 10.1038/srep38575.
10
Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding.核纤层蛋白突变通过核膜出芽导致线粒体mRNA输出缺陷从而加速衰老。
Curr Biol. 2016 Aug 8;26(15):2052-2059. doi: 10.1016/j.cub.2016.06.007. Epub 2016 Jul 21.
本文引用的文献
1
RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS.TDP-43 通过 UV-CLIP 识别的 RNA 靶标在 ALS 中失调。
Mol Cell Neurosci. 2011 Jul;47(3):167-80. doi: 10.1016/j.mcn.2011.02.013. Epub 2011 Mar 21.
2
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.长 pre-mRNA 耗竭和 RNA 错剪接导致 TDP-43 缺失引起神经元易损性。
Nat Neurosci. 2011 Apr;14(4):459-68. doi: 10.1038/nn.2779. Epub 2011 Feb 27.
3
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.鉴定 TDP-43 的 RNA 靶标和位置依赖的剪接调控。
Nat Neurosci. 2011 Apr;14(4):452-8. doi: 10.1038/nn.2778. Epub 2011 Feb 27.
4
Advances in understanding the molecular basis of FXTAS.理解脆性 X 智力低下震颤/共济失调综合征分子基础的进展。
Hum Mol Genet. 2010 Apr 15;19(R1):R83-9. doi: 10.1093/hmg/ddq166. Epub 2010 Apr 29.
5
Molecular therapy in myotonic dystrophy: focus on RNA gain-of-function.肌强直性营养不良的分子治疗：重点关注 RNA 获得性功能。
Hum Mol Genet. 2010 Apr 15;19(R1):R90-7. doi: 10.1093/hmg/ddq161. Epub 2010 Apr 20.
6
Spinal muscular atrophy: mechanisms and therapeutic strategies.脊髓性肌萎缩症：发病机制与治疗策略。
Hum Mol Genet. 2010 Apr 15;19(R1):R111-8. doi: 10.1093/hmg/ddq147. Epub 2010 Apr 13.
7
Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy.TDP-43 在肌萎缩侧索硬化症、额颞叶痴呆和其他神经退行性疾病以及 TDP-43 蛋白病的细胞模型中的磷酸化和切割。
Neuropathology. 2010 Apr;30(2):170-81. doi: 10.1111/j.1440-1789.2009.01089.x. Epub 2010 Jan 19.
8
Compromise in mRNA processing machinery in senescent human fibroblasts: implications for a novel potential role of Phospho-ATR (ser428).衰老的人成纤维细胞中 mRNA 加工机制的妥协：磷酸化 ATR（丝氨酸 428）的新的潜在作用的启示。
Biogerontology. 2010 Aug;11(4):421-36. doi: 10.1007/s10522-010-9261-z. Epub 2010 Jan 19.
9
MicroRNA group disorganization in aging.miRNA 簇在衰老中的紊乱。
Exp Gerontol. 2010 Apr;45(4):269-78. doi: 10.1016/j.exger.2009.12.009. Epub 2009 Dec 23.
10
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.TDP-43 相互作用蛋白的全局分析揭示了与 RNA 剪接和翻译机制的强烈关联。
J Proteome Res. 2010 Feb 5;9(2):1104-20. doi: 10.1021/pr901076y.
Zotero 插件