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J Org Chem. 2011 Oct 21;76(20):8262-9. doi: 10.1021/jo201425q. Epub 2011 Sep 7.
A POCl(3)-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing methods, this operationally simple protocol provides unique reactivity and functional group compatibility because of the metal-free, acidic reaction conditions. The yields are generally excellent.
本文描述了一种 POCl(3)介导的杂环酰胺/脲与 NH-杂环或 N-取代苯胺的直接胺化反应。与现有方法相比，由于无金属、酸性反应条件，这种操作简单的方案提供了独特的反应性和官能团兼容性。产率通常很高。
