• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

有界最大度矩阵的间隔连续1属性问题的复杂性

The complexity of the gapped consecutive-ones property problem for matrices of bounded maximum degree.

作者信息

Maňuch Ján, Patterson Murray

机构信息

Department of Mathematics, Simon Fraser University, Burnaby, Canada.

出版信息

J Comput Biol. 2011 Sep;18(9):1243-53. doi: 10.1089/cmb.2011.0128.

DOI:10.1089/cmb.2011.0128
PMID:21899429
Abstract

The Gapped Consecutive-Ones Property (C1P) Problem, or the (k, δ)-C1P Problem is: given a binary matrix M and integers k and δ, decide if the columns of M can be ordered such that each row contains at most k blocks of 1's, and no two neighboring blocks of 1's are separated by a gap of more than δ 0's. This problem was introduced by Chauve et al. ( 2009b ). The classical polynomial-time solvable C1P Problem is equivalent to the (1, 0)-C1P problem. It has been shown that, for every unbounded or bounded k ≥ 2 and unbounded or bounded δ ≥ 1, except when (k, δ) = (2, 1), the (k, δ)-C1P Problem is NP-complete (Maňuch et al., 2011 ; Goldberg et al., 1995 ). In this article, we study the Gapped C1P Problem with a third parameter d, namely the bound on the maximum number of 1's in any row of M, or the bound on the maximum degree of M. This is motivated by the reconstruction of ancestral genomes (Ma et al., 2006 ; Chauve and Tannier, 2008 ), where, in binary matrices obtained from the experiments of Chauve and Tannier ( 2008 ), we have observed that the majority of the rows have low degree, while each high degree row contains many rows of low degree. The (d, k, δ)-C1P Problem has been shown to be polynomial-time solvable when all three parameters are fixed (Chauve et al., 2009b ). Since fixing d also fixes k (k ≤ d), the only case left to consider is the case when δ is unbounded, or the (d, k, ∞)-C1P Problem. Here we show that for every d > k ≥ 2, the (d, k, ∞)-C1P Problem is NP-complete.

摘要

间隔连续1属性(C1P)问题,即(k, δ)-C1P问题是:给定一个二进制矩阵M以及整数k和δ,判断是否可以对M的列进行排序,使得每行最多包含k个由1组成的块,并且任意两个相邻的由1组成的块之间被0隔开的间隔不超过δ个。这个问题由肖夫等人(2009年b)提出。经典的多项式时间可解的C1P问题等同于(1, 0)-C1P问题。已经证明,对于每个无界或有界的k≥2以及无界或有界的δ≥1,除了(k, δ) = (2, 1)的情况外,(k, δ)-C1P问题是NP完全问题(马努赫等人,2011年;戈德堡等人,1995年)。在本文中,我们研究带有第三个参数d的间隔C1P问题,即M的任意一行中1的最大数量的界限,或者M的最大度数的界限。这是受祖先基因组重建问题的启发(马等人,2006年;肖夫和坦尼尔,2008年),在从肖夫和坦尼尔(2008年)的实验中得到的二进制矩阵里,我们观察到大多数行的度数较低,而每个高度数的行包含许多低度数的行。当所有三个参数都固定时,(d, k, δ)-C1P问题已被证明是多项式时间可解的(肖夫等人,2009年b)。由于固定d也会固定k(k≤d),剩下唯一需要考虑的情况是δ无界的情况,即(d, k, ∞)-C1P问题。在这里我们证明,对于每个d > k≥2,(d, k, ∞)-C1P问题是NP完全问题。

相似文献

1
The complexity of the gapped consecutive-ones property problem for matrices of bounded maximum degree.有界最大度矩阵的间隔连续1属性问题的复杂性
J Comput Biol. 2011 Sep;18(9):1243-53. doi: 10.1089/cmb.2011.0128.
2
Minimal conflicting sets for the consecutive ones property in ancestral genome reconstruction.祖先基因组重建中连续一致性属性的最小冲突集
J Comput Biol. 2010 Sep;17(9):1167-81. doi: 10.1089/cmb.2010.0113.
3
Linearization of ancestral multichromosomal genomes.祖先多染色体基因组的线性化。
BMC Bioinformatics. 2012;13 Suppl 19(Suppl 19):S11. doi: 10.1186/1471-2105-13-S19-S11. Epub 2012 Dec 19.
4
Determining a singleton attractor of a boolean network with nested canalyzing functions.确定具有嵌套 canalyzing 函数的布尔网络的单吸引子。
J Comput Biol. 2011 Oct;18(10):1275-90. doi: 10.1089/cmb.2010.0281. Epub 2011 May 9.
5
The zero exemplar distance problem.零范例距离问题。
J Comput Biol. 2011 Sep;18(9):1077-86. doi: 10.1089/cmb.2011.0097.
6
On realizing shapes in the theory of RNA neutral networks.关于RNA中性网络理论中的形状实现
J Theor Biol. 2005 Sep 21;236(2):216-27. doi: 10.1016/j.jtbi.2005.03.006.
7
Restricted DCJ model: rearrangement problems with chromosome reincorporation.受限DCJ模型:带染色体重新纳入的重排问题
J Comput Biol. 2011 Sep;18(9):1231-41. doi: 10.1089/cmb.2011.0116.
8
Maximum likelihood estimation of ordered multinomial parameters.有序多项参数的最大似然估计。
Biostatistics. 2004 Apr;5(2):291-306. doi: 10.1093/biostatistics/5.2.291.
9
On the identification of conflicting contiguities in ancestral genome reconstruction.
J Comput Biol. 2014 Jan;21(1):64-79. doi: 10.1089/cmb.2013.0086. Epub 2013 Oct 9.
10
Kernels for generalized multiple-instance learning.广义多实例学习的核函数。
IEEE Trans Pattern Anal Mach Intell. 2008 Dec;30(12):2084-98. doi: 10.1109/TPAMI.2007.70846.

引用本文的文献

1
Mapping ancestral genomes with massive gene loss: a matrix sandwich problem.利用大量基因丢失来绘制祖先基因组:矩阵三明治问题。
Bioinformatics. 2011 Jul 1;27(13):i257-65. doi: 10.1093/bioinformatics/btr224.