Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, Zhejiang, China.
Nat Prod Res. 2011 Oct;25(18):1707-12. doi: 10.1080/14786419.2011.553719. Epub 2011 Sep 8.
As a continuous work to find more epothilone congeners produced by the epothilones A and B producing Sorangium cellulosum strain So0157-2 in the large-scale fermentation (5000 L), we reinvestigated the chemical compositions of the fermentation broth. Consequently, two new epothilone variants (1-2) and one new natural epothilone derivative (3) were isolated from the fermentation broth. Their structures were established as 16-ethyl epothilone B (1), 6-desmethyl-16-hydroxymethyl epothilone C (2) and 20-ethyl epothilone A (3), respectively, by an extensive NMR analysis.
作为寻找更多由产埃博霉素 A 和 B 的索拉金菌菌株 So0157-2 在大规模发酵（5000L）中产生的埃博霉素同系物的持续工作的一部分，我们重新研究了发酵液的化学成分。结果，从发酵液中分离出两种新的埃博霉素变体（1-2）和一种新的天然埃博霉素衍生物（3）。通过广泛的 NMR 分析，它们的结构分别被确定为 16-乙基埃博霉素 B（1）、6-去甲基-16-羟甲基埃博霉素 C（2）和 20-乙基埃博霉素 A（3）。
