Agdestein Benedicte, Lindbæk Morten, Gjelstad Svein
Antibiotikasenteret for primærmedisin (ASP), Avdeling for allmennmedisin, HELSAM, Universitetet i Oslo, Norway.
Tidsskr Nor Laegeforen. 2011 Sep 6;131(17):1641-4. doi: 10.4045/tidsskr.10.0396.
Incorrect use of antibiotics is a major public health concern both nationally and globally due to the development of antibiotic resistance. The goal of this study was to see if prescription of antibiotics for urinary tract infections in general practice was in accordance with national guidelines.
We combined two sets of data from February and March 2003: prescriptions of antibiotics redeemed in pharmacies, and electronic billing cards collected from the National Insurance Agency from 145 general practitioners in Vestfold county. We analysed all consultations related to urinary tract problems, and we found which antibiotics had been prescribed and for how long. The treatment was then compared with the national guidelines. A logistic regression analysis identified factors associated with adequate treatment length.
Trimetoprime and mecillinam were most frequently prescribed to both genders. Sixty-nine (6 %) of the total 1,102 prescriptions were quinolones. A total of 271 (32 %) of 847 patients who were prescribed antibiotics for cystitis did not get treatment of sufficient length. Female and young patients were more often given the correct duration of treatment. Doctors with 1,000-1,500 patients more frequently prescribed sufficiently long treatment compared to other physicians. Six patients (0.5 %) were prescribed another antibiotic between two and 14 days after the first prescription.
The choice of antibiotics conformed well with national guidelines, but the duration of the treatment was often too short. In spite of this, only 0.5 % showed signs of relapse. A number of factors associated with adequate treatment length were identified. The empirical use of furadantin can be increased.
由于抗生素耐药性的发展,抗生素的不当使用在国内和全球都是一个重大的公共卫生问题。本研究的目的是了解全科医疗中尿路感染的抗生素处方是否符合国家指南。
我们合并了2003年2月和3月的两组数据:药房赎回的抗生素处方,以及从韦斯特福尔郡145名全科医生处收集的来自国家保险机构的电子计费卡。我们分析了所有与尿路问题相关的会诊,并确定了所开的抗生素及用药时长。然后将治疗情况与国家指南进行比较。逻辑回归分析确定了与足够治疗时长相关的因素。
甲氧苄啶和美西林是男女最常使用的抗生素。在总共1102张处方中,69张(6%)是喹诺酮类。在847名因膀胱炎而开了抗生素的患者中,共有271名(32%)没有得到足够时长的治疗。女性和年轻患者更常接受正确时长的治疗。与其他医生相比,拥有1000 - 1500名患者的医生更频繁地开出足够长疗程的治疗处方。6名患者(0.5%)在首次处方后的2至14天内被开了另一种抗生素。
抗生素的选择与国家指南相符,但治疗时长往往过短。尽管如此,只有0.5%的患者有复发迹象。确定了一些与足够治疗时长相关的因素。可以增加呋喃妥因的经验性使用。