Medical College, Soochow University, Suzhou 215123, People's Republic of China.
Biol Trace Elem Res. 2012 Mar;145(3):361-8. doi: 10.1007/s12011-011-9193-8. Epub 2011 Sep 8.
Due to increasing applications of lanthanides (Ln) in industry and daily life, numerous studies confirmed that Ln exposure may result in organ damages in mice and rats, while very few studies focused on several organs damages simultaneously. In order to compare the toxicity of Ln on organs, mice were exposed to LaCl(3), CeCl(3), and NdCl(3) of a dose of 20 mg/kg body weight for consecutive 60 days, respectively, then histopathological changes of liver, kidney, and heart, and their function were investigated. The results showed that long-term exposure to Ln caused cell necrosis and basophilia of liver, ambiguity of renal tubule architecture, congestion of blood vessel and capillary of kidney, and heart hemorrhage. The histopathological changes of liver, kidney, and heart in mice caused by Ce(3+) was most severe; the effect by Nd(3+) was slighter than Ce(3+) but more severe than La(3+). The assay of serum biochemical parameters suggested that Ln exposure severely impaired the functions of liver, kidney, and myocardium in mice. These findings suggested that long-term exposure to Ln resulted in histopathological changes of liver, kidney, and heart, and their function damages. Therefore, we thought that long-term application of the products containing Ln on human should be cautious.
由于镧系元素（Ln）在工业和日常生活中的应用日益增多，大量研究证实 Ln 暴露可能导致小鼠和大鼠的器官损伤，而很少有研究同时关注几种器官的损伤。为了比较 Ln 对器官的毒性，将小鼠分别暴露于 20mg/kg 体重的 LaCl3、CeCl3 和 NdCl3 中，连续 60 天，然后研究了肝、肾和心脏的组织病理学变化及其功能。结果表明，长期暴露于 Ln 可导致肝细胞核坏死和嗜碱性，肾小管结构模糊，肾血管和毛细血管充血，以及心脏出血。Ce（3+）引起的肝、肾和心组织病理学变化最为严重；Nd（3+）的作用比 Ce（3+）稍轻，但比 La（3+）更严重。血清生化参数测定表明，Ln 暴露严重损害了小鼠的肝、肾和心肌功能。这些发现表明，长期暴露于 Ln 会导致肝、肾和心脏的组织病理学变化及其功能损伤。因此，我们认为长期应用含有 Ln 的产品应谨慎。
