1型人类免疫缺陷病毒（HIV-1）感染的印度儿童中1型HIV包膜（V3-V5）序列的多样性
Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children.
作者信息
Prakash Somi Sankaran, Kalra Rajesh, Lodha Rakesh, Kabra Sushil K, Luthra Kalpana
机构信息
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
出版信息
AIDS Res Hum Retroviruses. 2012 May;28(5):505-9. doi: 10.1089/AID.2011.0206. Epub 2011 Sep 21.
Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children.
摘要 我们评估了来自印度北部13名感染HIV-1的印度儿童的病毒包膜（V3-V5区域）序列多样性。发现所有13名儿童均感染了C亚型病毒。其中一个病毒序列显示出Web PSSM和Geno2pheno工具预测的CXCR4共受体使用情况。该病毒还具有更长的V3序列，含37个氨基酸、一个GRGQ基序以及其之前的一个甲硫氨酸残基（AIIMS_307）。一个独特的发现是另一种病毒（AIIMS_363）的V4区域完全缺失。在感染HIV-1的印度儿童的包膜中观察到高度的序列多样性。
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