Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
J Microbiol. 2012 Oct;50(5):869-73. doi: 10.1007/s12275-012-2136-z. Epub 2012 Nov 4.
Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4 and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279 and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population.
对 21 名印度北部患者体内循环的人类免疫缺陷病毒 1 型的亚型进行了研究，其依据是包膜蛋白 gp120 的部分序列。大多数病毒（85.7%，18/21）为 C 亚型，而 A 亚型占 14.3%（3/21）。序列分析显示，与 V4 和 V5 相比，V3 区高度保守。预测的共受体使用表明，除了 2 株 A 亚型病毒（AIIMS279 和 AIIMS281）外，均只使用 R5。我们的研究结果表明 C 亚型病毒的 V3 环保守，提示在印度北部人群中出现了非 C 类病毒。
