Bossuyt Patrick M M
Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Klinische Epidemiologie, Biostatistiek en Bioinformatica, Amsterdam, the Netherlands.
Ned Tijdschr Geneeskd. 2011;155(35):A3859.
Biomarkers have become a popular topic in medicine, and investigations of putative molecular indicators of a specific biological state have started to occupy a considerable part of health research. Yet only a small number of biomarkers are being used in routine clinical practice. Many biomarker studies have major methodological shortcomings, in particular in the selection of appropriate study groups. Strong associations cannot always be replicated in later research.
