Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA.
Nutr Neurosci. 2011 Jul;14(4):165-78. doi: 10.1179/147683011X13009738172396.
Prenatal protein malnutrition alters the structure and function of the adult rat hippocampal formation. The current study examines the effect of prenatal protein malnutrition on numbers of parvalbumin-immunoreactive (PV-IR) GABAergic interneurons, which are important for perisomatic inhibition of hippocampal pyramidal neurons. Brain sections from prenatally protein malnourished and normally nourished rats were stained for parvalbumin and PV-IR neurons were quantified using stereology in the dentate gyrus, CA3/2 and CA1 subfields, and the subiculum for both cerebral hemispheres. Results demonstrated that prenatal malnutrition did not affect the number of PV-IR interneurons in the hippocampus. Since prenatal protein malnutrition reduces total neuron numbers in the CA1 subfield (1), this results in an altered ratio of PV-IR interneurons to total neuronal numbers (from 1:22.9 in controls to 1:20.5 in malnourished rats). Additionally, there was no hemispheric asymmetry of either PV-IR neuron numbers or ratio of PV-IR:total neuron numbers.
产前蛋白质营养不良会改变成年大鼠海马结构的结构和功能。本研究探讨了产前蛋白质营养不良对囊泡相关蛋白免疫反应性（PV-IR）GABA 能中间神经元数量的影响，这些神经元对于海马锥体神经元的胞体周围抑制很重要。用立体学方法对来自产前蛋白质营养不良和正常营养的大鼠脑切片进行染色，以确定齿状回、CA3/2 和 CA1 亚区以及两侧的下托中 PV-IR 神经元的数量。结果表明，产前营养不良并不影响海马中 PV-IR 中间神经元的数量。由于产前蛋白质营养不良会减少 CA1 亚区的总神经元数量（1），这导致了 PV-IR 中间神经元与总神经元数量的比例发生改变（从对照组的 1:22.9 变为营养不良组的 1:20.5）。此外，PV-IR 神经元数量或 PV-IR:总神经元数量的比值均没有半球不对称性。
