Department of Health Promotion Sciences G. D Alessandro-Hygiene section, University of Palermo, and Direzione Sanitaria-Azienda Ospedaliera Univesitaria Policlinico P. Glaccone, Palermo, Italy.
Euro Surveill. 2011 Sep 1;16(35):19957.
This paper describes the epidemiology of hospitalised cases with influenza-like illness (ILI) and laboratory-confirmed influenza A cases in Sicily (Italy) during the 2009 influenza pandemic. The first ILI case diagnosed as infected with pandemic influenza A(H1N1)2009 in Sicily was reported in June 2009 and it rapidly became the dominant circulating strain. In the period from 30 April 2009 through 31 December 2010, a total of 2,636 people in Sicily were hospitalised for ILI and 1,193 were laboratory-confirmed for influenza A. Basic demographic and clinical information for all hospitalised patients was collected and population mortality rates (PMRs) and case fatality ratios (CFRs) were calculated. The median age of hospitalised patients infected with pandemic influenza A(H1N1)2009 was significantly lower than that of hospitalised ILI cases in general (18.0 vs. 32.1 years; p<0.0001). Among adults, women were more susceptible than men. The majority of clinical presentations were mild, but 6.6% of hospitalised patients required admission to an intensive care unit, of whom 26.3% had confirmed influenza A. Twenty-four fatal cases were documented. The age group of 45–54 year-olds showed the highest PMRs once hospitalised, while CFRs were higher in elderly patients of 65 years and older. All fatal cases were confirmed as influenza A(H1N1)2009 and most of them had established risk factors for influenza complications.
本文描述了 2009 年流感大流行期间意大利西西里岛（意大利）住院流感样病例（ILI）和实验室确诊甲型流感病例的流行病学情况。西西里岛首例确诊为感染 2009 年甲型 H1N1 流感大流行的 ILI 病例报告于 2009 年 6 月，该病毒迅速成为主要流行株。在 2009 年 4 月 30 日至 2010 年 12 月 31 日期间，西西里岛共有 2636 人因 ILI 住院，1193 人实验室确诊为甲型流感。收集了所有住院患者的基本人口统计学和临床信息，并计算了人群死亡率（PMR）和病例死亡率（CFR）。感染 2009 年甲型 H1N1 流感大流行的住院患者的中位年龄明显低于一般 ILI 住院患者（18.0 岁 vs. 32.1 岁；p<0.0001）。在成年人中，女性比男性更易感。大多数临床表现为轻度，但 6.6%的住院患者需要入住重症监护病房，其中 26.3%的患者确诊为甲型流感。记录了 24 例死亡病例。一旦住院，45-54 岁年龄组的 PMR 最高，而 65 岁及以上的老年患者的 CFR 更高。所有死亡病例均被确认为 2009 年甲型 H1N1 流感，且大多数死亡病例均存在流感并发症的既定危险因素。
