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A network of regulatory pathways in lepromatous leprosy.

作者信息

Abbas Abul K

出版信息

Clin Immunol. 2011 Nov;141(2):127. doi: 10.1016/j.clim.2011.08.007. Epub 2011 Aug 18.

DOI:10.1016/j.clim.2011.08.007
PMID:21903479
Abstract
摘要

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Increased frequency of CD4 and CD8 regulatory T cells in individuals under 15 years with multibacillary leprosy.15岁以下多菌型麻风病患者体内CD4和CD8调节性T细胞频率增加。
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Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy.针对LID-1和NDO-LID的免疫球蛋白同种型的效用,尤其是IgG1,对于确诊多菌型麻风具有重要意义。
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Activated TLR2/4-positive T cells boost cell exhaustion during lepromatous leprosy infection via PD-1 upregulation.活化的TLR2/4阳性T细胞通过上调PD-1在瘤型麻风感染期间促进细胞耗竭。
Heliyon. 2022 Nov 15;8(11):e11633. doi: 10.1016/j.heliyon.2022.e11633. eCollection 2022 Nov.
2
Regulatory T-Cells at the Interface between Human Host and Pathogens in Infectious Diseases and Vaccination.传染病与疫苗接种中人类宿主和病原体界面的调节性T细胞
Front Immunol. 2015 May 11;6:217. doi: 10.3389/fimmu.2015.00217. eCollection 2015.