儿童及青少年甲状腺癌——文献系统综述
Thyroid carcinoma in children and adolescents-systematic review of the literature.
作者信息
Vaisman Fernanda, Corbo Rossana, Vaisman Mario
机构信息
Endocrinology Service, Universidade Federal do Rio de Janeiro, Rio de Janiro, RJ, Brazil.
出版信息
J Thyroid Res. 2011;2011:845362. doi: 10.4061/2011/845362. Epub 2011 Sep 4.
Abstract
Thyroid cancer in children and adolescents is usually a major concern for physicians, patients, and parents. Controversies regarding the aggressiveness of the clinical presentation and the ideal therapeutic approach remain among the scientific community. The current recommendations and staging systems are based on data generated by studies in adults, and this might lead to overtreating in some cases as well as undertreating in others. Understanding the differences in the biology, clinical course, and outcomes in this population is crucial for therapeutic decisions. This paper evaluates the biology, clinical presentation, recurrences, and overall survival as well as the staging systems in children and adolescents with differentiated thyroid cancer.
摘要
儿童和青少年甲状腺癌通常是医生、患者及家长主要关注的问题。科学界对于临床表现的侵袭性以及理想的治疗方法仍存在争议。当前的推荐和分期系统是基于成人研究产生的数据，这可能导致在某些情况下过度治疗，而在其他情况下治疗不足。了解该人群在生物学、临床病程及预后方面的差异对于治疗决策至关重要。本文评估了分化型甲状腺癌儿童和青少年的生物学特性、临床表现、复发情况、总生存率以及分期系统。
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