在氧化石墨烯溶液中，（Py）A 取代的寡聚脱氧腺苷酸的 pH 响应自双链作为分子开关。
pH-responsive self-duplex of (Py)A-substituted oligodeoxyadenylate in graphene oxide solution as a molecular switch.
机构信息
Laboratory for Modified Nucleic Acid Systems, Department of Chemistry, Division of IBB, Pohang University of Science and Technology, Pohang, South Korea.
出版信息
Org Biomol Chem. 2011 Nov 7;9(21):7434-8. doi: 10.1039/c1ob06037f. Epub 2011 Sep 8.
In this paper, we demonstrated a highly discriminated and reliable molecular switch based on the interaction between the self-duplex of (Py)A-substituted oligodeoxyadenylate and graphene oxide in aqueous solution. This system showed a clear on/off state through the association and dissociation of (Py)A-modified oligodeoxynucleotide with graphene oxide in manipulated pH conditions, high amplitude efficiency for at least 50 cycles, and rapid response within seconds. Our molecular switch system has high reproducibility and simple operation by using pH stimulus.
在本文中，我们展示了一种基于（Py）A 取代的寡脱氧腺苷酸的自身双链体与水溶液中的氧化石墨烯相互作用的高分辨和可靠的分子开关。该系统通过在 pH 值条件下操纵（Py）A 修饰的寡脱氧核苷酸与氧化石墨烯的结合和解离，显示出明显的开/关状态，效率高，至少 50 个循环，响应迅速，在几秒钟内。我们的分子开关系统通过 pH 刺激具有高重现性和简单的操作。
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