基于金包覆磁性纳米粒子簇和动态光散射的甲胎蛋白灵敏免疫分析方法
A facile and sensitive immunoassay for the detection of alpha-fetoprotein using gold-coated magnetic nanoparticle clusters and dynamic light scattering.
机构信息
Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea.
出版信息
Chem Commun (Camb). 2011 Oct 21;47(39):11047-9. doi: 10.1039/c1cc14024h. Epub 2011 Sep 9.
PMID:21904752
Abstract
A facile and sensitive immunoassay protocol for the detection of alpha-fetoprotein (AFP) was developed using gold-coated iron oxide magnetic nanoclusters and dynamic light scattering (DLS) methods. The increase in the average particle size due to AFP-mediated aggregation was measured using DLS, and the detection limit was better than 0.01 ng mL(-1).
摘要
本研究使用金包覆的磁性纳米簇和动态光散射（DLS）方法，开发了一种用于检测甲胎蛋白（AFP）的简便、灵敏的免疫分析方法。利用 DLS 测量了由于 AFP 介导的聚集导致的平均粒径增加，检测限优于 0.01ng/mL。
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