Department of Nuclear Medicine, Charité, Augustenburger Platz 1, 13353 Berlin, Germany.
Eur Radiol. 2012 Feb;22(2):458-67. doi: 10.1007/s00330-011-2266-4. Epub 2011 Sep 9.
This study was performed to assess the role of retrospective PET-MRI fusion with Ga-68-DOTA(0)-Phe(1)-Tyr(3)-octreotide (Ga-68-DOTATOC) PET and Gd-EOB-DTPA MRI in the detection of hepatic metastases from neuroendocrine tumours (NET).
Twenty-two consecutive patients with suspected liver metastases from histopathologically proven NET were examined with Gd-EOB-DTPA MRI and multiphase contrast-enhanced Ga-68-DOTATOC PET/CT. PET and MRI images were retrospectively fused using commercially available software. Two physicians experienced in nuclear medicine and radiology analysed the images to assess diagnostic confidence and characterise liver lesions.
A total of 181 lesions were detected. PET-MRI showed a sensitivity of 91.2% (significantly superior to PET/CT; P < 0.05) and a specificity of 95.6% (significantly superior to MRI; P < 0.05). PET/CT had a sensitivity of 73.5% and a specificity of 88.2%. MRI had a sensitivity of 87.6% and a specificity of 86.8%. The area under the curve was 0.98 for PET-MRI, 0.96 for MRI, and 0.89 for PET/CT (P < 0.05).
Retrospectively fused PET-MRI was superior to multiphase contrast-enhanced Ga-68-DOTATOC PET/CT and Gd-EOB-DTPA MRI in the detection of NET liver metastases. It was more sensitive than PET/CT and more specific than MRI. Fused PET-MRI therefore seems well suited for surgical and interventional treatment planning of NET liver metastases.
• Ga-68-DOTATOC PET-Gd-EOB-DTPA MRI fusion can improve imaging of liver metastases of neuroendocrine tumours. • This technique appears more sensitive than PET/CT for staging NET hepatic metastases. • Ga-68-DOTATOC PET-Gd-EOB-DTPA MRI fusion is more specific than MRI alone.
本研究旨在评估 Ga-68-DOTA(0)-Phe(1)-Tyr(3)- 奥曲肽（Ga-68-DOTATOC）PET 和 Gd-EOB-DTPA MRI 融合的回顾性 PET-MRI 在神经内分泌肿瘤（NET）肝转移中的作用。
对 22 例经组织病理学证实的 NET 肝转移疑似患者进行 Gd-EOB-DTPA MRI 和多期增强 Ga-68-DOTATOC PET/CT 检查。使用商业软件对 PET 和 MRI 图像进行回顾性融合。两位具有核医学和放射学经验的医生分析图像以评估诊断信心并描述肝脏病变。
共检测到 181 个病灶。PET-MRI 的敏感性为 91.2%（明显优于 PET/CT；P<0.05），特异性为 95.6%（明显优于 MRI；P<0.05）。PET/CT 的敏感性为 73.5%，特异性为 88.2%。MRI 的敏感性为 87.6%，特异性为 86.8%。PET-MRI 的曲线下面积为 0.98，MRI 为 0.96，PET/CT 为 0.89（P<0.05）。
回顾性融合 PET-MRI 在 NET 肝转移的检测中优于多期增强 Ga-68-DOTATOC PET/CT 和 Gd-EOB-DTPA MRI。它比 PET/CT 更敏感，比 MRI 更特异。因此，融合后的 PET-MRI 似乎非常适合 NET 肝转移的手术和介入治疗计划。
Ga-68-DOTATOC PET-Gd-EOB-DTPA MRI 融合可改善神经内分泌肿瘤肝转移的成像。
对于 NET 肝转移的分期，该技术比 PET/CT 更敏感。
Ga-68-DOTATOC PET-Gd-EOB-DTPA MRI 融合比单独 MRI 更特异。
