Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel.
Prenat Diagn. 2011 Dec;31(12):1115-9. doi: 10.1002/pd.2840. Epub 2011 Sep 8.
The aim of this study was to characterize the normal ultrasonographic growth of the corpus callosum (CC) in normal and in growth-restricted fetuses throughout gestation.
This was a prospective cross-sectional study. Consecutive routine biometric measurements and fetal organ scans were obtained in patients undergoing elective fetal anatomical surveys or evaluation of the fetal growth between 16 to 33 weeks. Special attention was given to the CC of the fetal brain. In addition, we evaluated the growth of the CC in growth-restricted fetuses throughout pregnancy.
Two hundred and fifty two normal fetuses were scanned between 16 and 36 weeks of gestation. A regression line of the CC was established through gestation and a second-degree correlation was found between gestational age and CC outer margin. Twenty four growth-restricted fetuses were also evaluated in which the growth of the CC was significantly below both the 25(th) and 50(th) percentiles in 77.3% and 95.5%, respectively, for the same gestational age.
We provide nomograms for the ultrasonographic dimensions of the fetal CC that allows for prenatal diagnosis of abnormal dimensions of CC. The significance of abnormal CC growth in growth-restricted fetuses should be further evaluated.
本研究旨在描述正常胎儿和生长受限胎儿在整个妊娠期胼胝体（CC）的正常超声生长特征。
这是一项前瞻性的横断面研究。对在 16 至 33 周期间接受常规胎儿解剖学检查或胎儿生长评估的患者连续进行常规生物测量和胎儿器官扫描。特别关注胎儿大脑的 CC。此外，我们还评估了生长受限胎儿整个孕期 CC 的生长情况。
在 16 至 36 周的妊娠期间，对 252 例正常胎儿进行了扫描。通过妊娠建立了 CC 的回归线，并发现了妊娠龄与 CC 外边缘之间的二次相关关系。还评估了 24 例生长受限的胎儿，其中 CC 的生长在相同的妊娠龄下，分别在 77.3%和 95.5%的情况下显著低于第 25 百分位数和第 50 百分位数。
我们提供了胎儿 CC 超声尺寸的正常值图表，可用于产前诊断 CC 尺寸异常。生长受限胎儿 CC 生长异常的意义应进一步评估。
