Institute for Pathology, Sana Klinikum Lichtenberg, Berlin, Germany.
Ann Neurol. 2011 Sep;70(3):515-8. doi: 10.1002/ana.22522.
A role for Epstein-Barr virus (EBV) in myasthenia gravis pathogenesis has been suggested recently. Using in situ hybridization for the detection of the EBV-encoded RNAs and EBNA1-specific immunohistochemistry, we found no latently infected cells in a series of thymus specimens from patients with myasthenia gravis showing lymphofollicular thymitis. In addition, using immunohistochemistry and an antibody specific for the viral immediate early protein BZLF1, no evidence of lytic EBV infection was seen in these cases. Our results therefore do not support a direct role of thymic EBV infection in the pathogenesis of myasthenia gravis.
最近有研究提示，爱泼斯坦-巴尔病毒（EBV）在重症肌无力发病机制中起作用。我们应用原位杂交检测 EBV 编码的 RNA 和 EBNA1 特异性免疫组化，在一系列重症肌无力患者的胸腺瘤标本中未发现潜伏感染的细胞。此外，应用免疫组化和针对病毒早期蛋白 BZLF1 的抗体，在这些病例中也未发现 EBV 裂解性感染的证据。因此，我们的结果不支持胸腺瘤 EBV 感染在重症肌无力发病机制中的直接作用。
