Huang George T J
Boston University, Henry Goldman School of Dental Medicine, Department of Endodontics, 100 E. Newton St. G-705, Boston, MA 02118, USA.
Alpha Omegan. 2011 Spring;104(1-2):46-51.
Recently, two new clinical concepts have emerged for the management of endodontically compromised immature permanent teeth. One involves a revitalization approach to achieve tissue generation and regeneration in the root canal system. In this method, new living tissue is expected to form in the cleaned canal space allowing continued root development in terms of both length and thickness. The other is the active pursuit of pulp/dentine regeneration via tissue engineering technology to implant or re-grow pulps. Although the technology is still at its infancy, it has potential to benefit immature pulpless teeth by allowing continued growth and maturation. Evidence has shown that using dental stem cells, pulp and dentin can be regenerated in the root canal space. It is foreseeable that a decade or two from now, regenerative endodontics is likely to be an alternative treatment modality for clinical endodontics. It is therefore important for us to understand stem cells and tissue regeneration and be prepared for this clinical practice.
最近，针对牙髓受损的未成熟恒牙的治疗出现了两个新的临床概念。一个是采用一种修复方法，以实现根管系统中的组织生成和再生。在这种方法中，预期在清理后的根管空间内形成新的活组织，从而使牙根在长度和厚度方面都能继续发育。另一个是通过组织工程技术积极寻求牙髓/牙本质再生，以植入或重新生长牙髓。尽管这项技术仍处于起步阶段，但它有潜力通过促进牙根的持续生长和成熟，使未成熟的无髓牙受益。有证据表明，利用牙干细胞，可以在根管空间内实现牙髓和牙本质的再生。可以预见，从现在起的一二十年里，再生牙髓病学很可能成为临床牙髓病学的一种替代治疗方式。因此，我们了解干细胞和组织再生并为这种临床实践做好准备是很重要的。
