精神分裂症小脑蚓部脑回指数降低：一项尸体研究。
Reduction of gyrification index in the cerebellar vermis in schizophrenia: a post-mortem study.
机构信息
Department of Psychiatry and Psychotherapy, University of Goettingen, von-Siebold Str. 5, 37075 Goettingen, Germany.
出版信息
World J Biol Psychiatry. 2011 Sep;12 Suppl 1:99-103. doi: 10.3109/15622975.2011.598379.
OBJECTIVES
In schizophrenia, alterations of the gyrification index (GI) have been measured in cortical brain regions and are related to neurodevelopmental disturbances. Cerebellar regions have been implicated in the pathophysiology of schizophrenia; however, the GI has not been investigated here so far.
METHODS
Hence, in a post-mortem study we investigated the GI separately from the vermis, left and right hemisphere of the medial posterior cerebellum in nine schizophrenia patients and 10 healthy controls. GI was defined as length of the inner contour inclusively depth of the sulci divided by length of the outer contour of the cerebellar surface and measured by tracing contours on images obtained by a stereological workstation.
RESULTS
In the vermis, GI was reduced in schizophrenia patients according to the methods of Zilles (P = 0.020) and Vogeley (P = 0.015). In the hemispheres, no differences have been observed. GI obtained by the two methods showed a high correlation (P < 0.001). Correlation analysis showed no influence of gender, postmortem interval and age.
CONCLUSIONS
Decreased GI in the vermis of schizophrenia patients may result from neurodevelopmental disturbances, since folding of the brain occurs mainly during the perinatal period. MRI studies using automated GI processing in larger samples are needed to confirm our results.
目的
在精神分裂症中，脑回指数（GI）的改变已在皮质脑区进行了测量，并且与神经发育障碍有关。小脑区域与精神分裂症的病理生理学有关；然而，迄今为止尚未对此进行 GI 研究。
方法
因此，在一项尸体研究中，我们分别研究了 9 名精神分裂症患者和 10 名健康对照者的小脑后内侧的蚓部、左侧和右侧的 GI。GI 被定义为内侧轮廓的长度（包括沟的深度）除以小脑表面的外部轮廓的长度，并通过在体视学工作站获得的图像上追踪轮廓来测量。
结果
根据 Zilles 方法（P = 0.020）和 Vogeley 方法（P = 0.015），蚓部的 GI 在精神分裂症患者中降低。在半球中，没有观察到差异。两种方法获得的 GI 相关性很高（P < 0.001）。相关性分析显示，性别、死后间隔和年龄没有影响。
结论
精神分裂症患者蚓部的 GI 降低可能是由于神经发育障碍引起的，因为大脑的折叠主要发生在围产期。需要使用自动 GI 处理的更大样本的 MRI 研究来证实我们的结果。
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