Todd R F, Mizukami I F, Vinjamuri S D, Trochelman R D, Hancock W W, Liu D Y
Department of Internal Medicine, Simpson Memorial Institute, University of Michigan Medical School, Ann Arbor 48109.
Blood Cells. 1990;16(1):167-79; discussion 180-2.
Activation of mononuclear phagocytes causes changes in plasma membrane composition that include the expression of surface antigens and receptors. Monoclonal antibody technology has made it possible to identify and characterize newly expressed surface antigens. Among these "activation antigens" is a glycoprotein, Mo3, which (among hematopoietic cells) is selectively expressed by human mononuclear phagocytes that have been exposed to inflammatory factors in vitro and in vivo. Progress toward a functional and structural analysis of Mo3 is described.
单核吞噬细胞的激活会导致质膜组成发生变化，其中包括表面抗原和受体的表达。单克隆抗体技术使鉴定和表征新表达的表面抗原成为可能。在这些“激活抗原”中，有一种糖蛋白Mo3，它（在造血细胞中）由在体外和体内暴露于炎症因子的人单核吞噬细胞选择性表达。本文描述了对Mo3进行功能和结构分析的进展。
