Leff J A, Repine J E
Department of Medicine, University of Colorado Health Sciences Center, Denver.
Blood Cells. 1990;16(1):183-91; discussion 191-2.
Ischemia-reperfusion insults are common clinical problems which involve most notably the heart (myocardial infarction) and brain (stroke). However, these and other organs are susceptible to damage following warming after cold injury, trauma, shock, and/or preparation for transplantation. Although the mechanisms responsible for reperfusion damage following ischemia and reperfusion are unknown, they are the focus of intense interest and investigation. This review briefly addresses our recent research related to the potential contributions of blood cells to the development of ischemia-reperfusion injury.
缺血再灌注损伤是常见的临床问题，最显著涉及心脏（心肌梗死）和大脑（中风）。然而，在冷损伤、创伤、休克和/或移植准备后的复温过程中，这些器官以及其他器官都易受损伤。尽管缺血和再灌注后负责再灌注损伤的机制尚不清楚，但它们是人们强烈关注和研究的焦点。本综述简要阐述了我们最近关于血细胞对缺血再灌注损伤发展的潜在作用的研究。
