Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
Int Rev Neurobiol. 2011;99:169-89. doi: 10.1016/B978-0-12-387003-2.00007-0.
The neural underpinnings of sensorimotor integration are best studied in the context of well-characterized behavior. A rich trove of Drosophila behavioral genetics research offers a variety of well-studied behaviors and candidate brain regions that can form the bases of such studies. The development of tools to perform in vivo physiology from the Drosophila brain has made it possible to monitor activity in defined neurons in response to sensory stimuli. More recently still, it has become possible to perform recordings from identified neurons in the brain of head-fixed flies during walking or flight behaviors. In this chapter, we discuss how experiments that simultaneously monitor behavior and physiology in Drosophila can be combined with other techniques to produce testable models of sensorimotor circuit function.
感觉运动整合的神经基础最好在经过充分描述的行为背景下进行研究。丰富的果蝇行为遗传学研究提供了各种经过充分研究的行为和候选脑区，可作为此类研究的基础。开发用于从果蝇大脑进行体内生理学研究的工具，使得监测对感觉刺激的反应的特定神经元的活动成为可能。最近，仍然有可能在头部固定的果蝇进行行走或飞行行为时，对大脑中的特定神经元进行记录。在本章中，我们讨论了如何将同时监测果蝇行为和生理学的实验与其他技术相结合，以产生感觉运动回路功能的可测试模型。
