Boström L, Ringdén O, Gratama J W, Jacobsen N, Prentice H G, Zwaan F E, Nilsson B
The Bone Marrow Transplantation Team at Huddinge Hospital, Sweden.
Bone Marrow Transplant. 1990 May;5(5):321-6.
Pretransplant herpes virus serology and acute graft-versus-host disease (GVHD) were studied in 379 leukaemic bone marrow transplant (BMT) recipients and their HLA-identical sibling donors. In logistic multivariate regression analysis pretransplant seropositivity to three or more different herpes viruses among the recipients was the only significant factor associated with grade II-IV acute GVHD (p = 0.03). If this factor was excluded, older donor age (p less than 0.001), absence of T cell depletion (p less than 0.001), pharmacological immunosuppression by monotherapy of methotrexate or cyclosporin versus a combination therapy of both (p = 0.002), and seropositivity to three or more herpes viruses among the donors (p = 0.03) prior to BMT, were also significantly associated with acute GVHD. The data indicate that latent herpes viruses in the host may act as minor histocompatibility antigens or by other means to trigger acute GVHD.
对379例白血病骨髓移植（BMT）受者及其HLA匹配的同胞供者进行了移植前疱疹病毒血清学和急性移植物抗宿主病（GVHD）的研究。在逻辑多元回归分析中，受者移植前对三种或更多种不同疱疹病毒血清反应阳性是与Ⅱ-Ⅳ级急性GVHD相关的唯一显著因素（p = 0.03）。如果排除该因素，供者年龄较大（p＜0.001）、未进行T细胞去除（p＜0.001）、甲氨蝶呤或环孢素单一药物治疗与两者联合治疗相比的药物免疫抑制（p = 0.002）以及移植前供者对三种或更多种疱疹病毒血清反应阳性（p = 0.03），也与急性GVHD显著相关。数据表明，宿主中的潜伏疱疹病毒可能作为次要组织相容性抗原或以其他方式引发急性GVHD。
