非对映 4-脱氧-4-氟碳水化合物的合成及 NMR 谱表征。

Syntheses and NMR characterizations of epimeric 4-deoxy-4-fluoro carbohydrates.

机构信息

Chemical Development, sanofi-aventis US, 1041 Route 202-206, Bridgewater, NJ 08807, USA.

出版信息

Carbohydr Res. 2011 Nov 8;346(15):2323-6. doi: 10.1016/j.carres.2011.07.019. Epub 2011 Jul 26.

DOI:10.1016/j.carres.2011.07.019

PMID:21906726

Abstract

The synthesis and NMR characterizations of 1,2,3,6-tetra-O-benzoyl-4-deoxy-4-fluoro-β-d-galactopyranoside, the 4-deoxy-4-fluoro epimer of an intermediate in the synthesis of a drug substance, needed for use as a potential impurity standard and to confirm the stereoselectivity of a key fluorination step, are described.

摘要

1,2,3,6-四-O-苯甲酰基-4-去氧-4-氟-β-D-半乳糖吡喃糖苷的合成及 NMR 谱表征，该化合物是一种药物合成中间体的 4-去氧-4-氟差向异构体，需要用作潜在的杂质标准品，并确认关键氟化步骤的立体选择性。