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The pyrazoloacridines: approaches to the development of a carcinoma-selective cytotoxic agent.

作者信息

Jackson R C, Sebolt J S, Shillis J L, Leopold W R

机构信息

Chemotherapy Department, Parke-Davis Pharmaceutical Research Division, Ann Arbor, Michigan 48105.

出版信息

Cancer Invest. 1990;8(1):39-47. doi: 10.3109/07357909009017545.

DOI:10.3109/07357909009017545
PMID:2190673
Abstract
摘要

相似文献

1
The pyrazoloacridines: approaches to the development of a carcinoma-selective cytotoxic agent.
Cancer Invest. 1990;8(1):39-47. doi: 10.3109/07357909009017545.
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Pyrazoloacridines, a new class of anticancer agents with selectivity against solid tumors in vitro.
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Activity of the pyrazoloacridines against multidrug-resistant tumor cells.
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The role of structural factors in the kinetics of cellular uptake of pyrazoloacridines and pyrazolopyrimidoacridines: implications for overcoming multidrug resistance towards leukaemia K562/DOX cells.结构因素在吡唑并吖啶和吡唑并嘧啶吖啶细胞摄取动力学中的作用：对克服白血病K562/DOX细胞多药耐药性的启示
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[Acridines as antitumor drugs].
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Comparative molecular field analysis of in vitro growth inhibition of L1210 and HCT-8 cells by some pyrazoloacridines.某些吡唑并吖啶对L1210和HCT-8细胞体外生长抑制的比较分子场分析
J Med Chem. 1993 Nov 12;36(23):3511-6. doi: 10.1021/jm00075a004.
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Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II.吡唑并吖啶（NSC 366140）对DNA拓扑异构酶I和II的作用。
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The ability to overcome multidrug resistance of tumor cell lines by novel acridine cytostatics with condensed heterocyclic rings.具有稠合杂环的新型吖啶类细胞抑制剂克服肿瘤细胞系多药耐药性的能力。
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Pyrimido [4,5,6-kl] acridines, a new class of potential anticancer agents. Synthesis and biological evaluation.嘧啶并[4,5,6 - kl]吖啶类化合物，一类新型潜在抗癌剂。合成与生物学评价。
Anticancer Drug Des. 1996 Jun;11(4):339-49.

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Phase II trial of pyrazoloacridine (NSC#366140) in patients with metastatic breast cancer.吡唑并吖啶（NSC#366140）治疗转移性乳腺癌患者的 II 期临床试验。
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Phase I/II trial of pyrazoloacridine and carboplatin in patients with recurrent glioma: a North Central Cancer Treatment Group trial.吡唑并吖啶与卡铂治疗复发性胶质瘤患者的I/II期试验：一项中北部癌症治疗组试验
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A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer.吡唑并吖啶（NSC 366140）与卡铂用于晚期癌症患者的I期和药理学研究。
Invest New Drugs. 2002 Aug;20(3):297-304. doi: 10.1023/a:1016237426846.
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Invest New Drugs. 2000 Aug;18(3):265-7. doi: 10.1023/a:1006434008357.
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Current status of pyrazoloacridine as an anticancer agent.吡唑并吖啶作为抗癌剂的现状。
Invest New Drugs. 1999;17(1):43-8. doi: 10.1023/a:1006242321596.
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