描绘 p53 激活：癌症的一个新核仁联系。
DePICTing p53 activation: a new nucleolar link to cancer.
机构信息
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.
出版信息
Cancer Cell. 2011 Sep 13;20(3):283-4. doi: 10.1016/j.ccr.2011.08.017.
PMID:21907918
Abstract
p53 activation by ribosomal biogenesis stress is important for tumor suppression. In the August issue of Nature Medicine, Sasaki et al. identify PICT1 as a regulator of this process. PICT1 sequesters ribosomal protein RPL11 in the nucleolus, attenuating p53 induction. Excessive PICT1 may dampen the p53 response and promote cancer.
摘要
核糖体生物发生应激引发的 p53 激活对于肿瘤抑制非常重要。在《自然医学》杂志 8 月刊上，Sasaki 等人确定 PICT1 是这一过程的调节因子。PICT1 将核糖体蛋白 RPL11 隔离在核仁中，从而减弱 p53 的诱导。过量的 PICT1 可能会抑制 p53 反应并促进癌症。
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