Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Diabetes Res Clin Pract. 2012 Jan;95(1):19-24. doi: 10.1016/j.diabres.2011.08.013. Epub 2011 Sep 9.
To know which MS criteria best predict the presence of NAFLD and the prevalences of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) diagnosed ultrasonographically among pre-diabetic and diabetic subjects based on three different MS criteria (IDF, ATP III, WHO).
Subjects were screened and those with a fasting serum glucose level ≥100 mg/dL were further tested with a 75 g oral glucose tolerance test. And those who were newly diagnosed as having pre-diabetes or diabetes were evaluated for MS and NAFLD. We compared the risk ratios of NAFLD among three MS criteria using multivariate and multiple logistic regression analyses.
A total of 1365 subjects (977 males, mean age 48.4±9.5 years) were analyzed. The WHO criteria produced the highest prevalence of MS in both the pre-diabetic (49.8%) and diabetic (58.9%) groups. The IDF criteria produced the highest odds ratio for NAFLD in both pre-diabetic (3.89 [95% CI 2.75-5.51]) and diabetic (5.53 [95% CI 3.21-9.52]) groups.
The prevalence of MS depends on the set of diagnostic criteria used. IDF criteria best predicts the presence of NAFLD. The presence of NAFLD should be considered as a component of the diagnostic criteria for MS.
了解基于三种不同代谢综合征（MS）标准（IDF、ATP III、WHO），哪些 MS 标准最能预测糖尿病前期和糖尿病患者中非酒精性脂肪性肝病（NAFLD）的存在以及代谢综合征和非酒精性脂肪肝的患病率。
对受试者进行筛查，空腹血清葡萄糖水平≥100mg/dL 的受试者进一步进行 75g 口服葡萄糖耐量试验。新诊断为糖尿病前期或糖尿病的患者评估 MS 和 NAFLD。我们使用多变量和多元逻辑回归分析比较了三种 MS 标准中 NAFLD 的风险比。
共分析了 1365 名受试者（977 名男性，平均年龄 48.4±9.5 岁）。在糖尿病前期（49.8%）和糖尿病（58.9%）组中，WHO 标准产生的 MS 患病率最高。在糖尿病前期（3.89[95%CI2.75-5.51]）和糖尿病（5.53[95%CI3.21-9.52]）组中，IDF 标准对 NAFLD 的比值比最高。
MS 的患病率取决于所使用的诊断标准集。IDF 标准最能预测 NAFLD 的存在。NAFLD 的存在应被视为 MS 诊断标准的组成部分。
