Yasuno Kyohei, Takagi Yoshiichi, Kobayashi Ryosuke, Ohmuro Tamio, Kamiie Junichi, Sahara Hiroeki, Shirota Kinji
Research Institute of Biosciences, School of Veterinary Medicine, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
J Vet Diagn Invest. 2011 Jul;23(4):832-5. doi: 10.1177/1040638711406973.
The current report describes a complex canine mammary adenoma with a rare histological feature characterized by sebaceous differentiation of tumor cells. A 13-year-old, mixed-breed, intact female dog had mammary tumors on the right mammary chain. Histologically, one of the masses was composed of bilayered ductal structures with luminal epithelial cells together with basaloid or myoepithelial cell components. Within the tumor, there were a number of lobules and nests of large foamy cells associated with basaloid reserve-like cells similar to sebaceous gland. Squamous metaplasia was also seen within the tumor. Immunohistochemical staining indicated that the tumor cells with sebaceous differentiation were positive for cytokeratin (CK)14 and that the associated basaloid reserve-like cells were positive for p63. In contrast, other luminal epithelial tumor cells were positive for CK18 and CK19, but not for CK14 and p63. The myoepithelial cells were positive for α-smooth muscle actin and p63. The expression of p63 in both sebaceous basaloid reserve-like cells and myoepithelial cells, and their structural continuity within the tumor tissue, suggested a common origin of these 2 components.
本报告描述了一例具有罕见组织学特征的复杂犬乳腺腺瘤，其特征为肿瘤细胞的皮脂腺分化。一只13岁的未绝育混种雌性犬右侧乳腺链出现乳腺肿瘤。组织学上，其中一个肿块由双层导管结构组成，管腔上皮细胞与基底样或肌上皮细胞成分并存。肿瘤内有许多大的泡沫细胞小叶和巢，与类似皮脂腺的基底样储备样细胞相关。肿瘤内还可见鳞状化生。免疫组化染色显示，具有皮脂腺分化的肿瘤细胞细胞角蛋白（CK）14呈阳性，相关的基底样储备样细胞p63呈阳性。相比之下，其他管腔上皮肿瘤细胞CK18和CK19呈阳性，但CK14和p63呈阴性。肌上皮细胞α平滑肌肌动蛋白和p63呈阳性。皮脂腺基底样储备样细胞和肌上皮细胞中p63的表达以及它们在肿瘤组织中的结构连续性，提示这两种成分有共同起源。
