S. Croce e Carle Hospital, Italy.
Cephalalgia. 2011 Oct;31(14):1497-502. doi: 10.1177/0333102411418260. Epub 2011 Sep 9.
To study the link between nonverbal learning disorder and right cerebral hemisphere dysfunction due to migraine attack in a case of Familial Hemiplegic Migraine.
Familial Hemiplegic Migraine can cause neuropsychological deficits besides the motor ones. The nonverbal learning disorder is thought to be caused by a right hemisphere dysfunction.
We describe a child with Familial Hemiplegic Migraine type 2 who showed a transient neuropsychological impairment featuring a nonverbal learning disorder during and after a Hemiplegic migraine attack.
Clinical and neuropsychological data showed a nonverbal learning disorder. A mutation in the ATP1A2 gene on chromosome 1q23 was found. Symptoms of nonverbal learning disorder outlasted the left hemiparesis. Two months later he showed a full recovery. Neurophysiological and neuroradiological evaluations were congruent with clinical course and with right hemisphere involvement.
The link between nonverbal learning disorder and right cerebral hemisphere dysfunction due to migraine attack is confirmed. Familial Hemiplegic Migraine can cause transient complex neuropsychological syndromes that can be overlooked if not appropriately investigated.
研究偏头痛发作导致右侧大脑半球功能障碍与非言语性学习障碍之间的联系，病例为家族性偏瘫性偏头痛。
家族性偏瘫性偏头痛除运动障碍外，还可引起神经心理学缺陷。非言语性学习障碍被认为是由右半球功能障碍引起的。
我们描述了一例 2 型家族性偏瘫性偏头痛患儿，在偏瘫性偏头痛发作期间和之后出现短暂的神经心理学损伤，表现为非言语性学习障碍。
临床和神经心理学数据显示存在非言语性学习障碍。发现 1q23 染色体上的 ATP1A2 基因突变。非言语性学习障碍的症状持续存在，直到左侧偏瘫完全恢复。两个月后他完全康复。神经生理学和神经影像学评估与临床过程和右侧受累一致。
偏头痛发作导致的非言语性学习障碍与右侧大脑半球功能障碍之间的联系得到证实。家族性偏瘫性偏头痛可引起短暂的复杂神经心理学综合征，如果不进行适当的检查，可能会被忽视。
