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罗红霉素与多西环素治疗宫颈炎的比较:在实际相关条件下的前瞻性随机多中心研究

[Roxithromycin versus doxycycline in the treatment of cervicitis. Prospective randomized multicenter study under practice-related conditions].

作者信息

Hoyme U B, Alimi M, Feldmann H U, Gerlach H, Keuter U, Marks H J, Moayer M, Salih A F, Schindler A E, Stangier H J

机构信息

Zentrum für Frauenheilkunde, Universitätsklinikum Essen.

出版信息

Fortschr Med. 1990 Apr 20;108(12):244-6.

PMID:2190897
Abstract

In a prospective randomized multicenter study Roxithromycin 150 mg or Doxycycline 100 mg was given b.i.d. p.o. for ten days to women with clinically diagnosed cervicitis. All women were seen as outpatients by one of eight licensed gynecologists in their private office in the Essen city area. With a cure and improvement rate of 100% in those women who completed therapy, Roxithromycin (n = 106) was as effective as Doxycycline (n = 104; 98%). At 90% Roxithromycin was as well tolerated as Doxycycline at 93%. Both drugs were clinically and microbiologically effective in eradicating Chlamydia trachomatis.

摘要

在一项前瞻性随机多中心研究中,对临床诊断为宫颈炎的女性口服给予150毫克罗红霉素或100毫克强力霉素,每日两次,持续10天。所有女性均由埃森市地区私人诊所的八位有执照的妇科医生之一作为门诊患者进行诊治。在完成治疗的女性中,罗红霉素组(n = 106)的治愈率和改善率为100%,与强力霉素组(n = 104;98%)效果相同。罗红霉素的耐受性为90%,与强力霉素的93%相当。两种药物在根除沙眼衣原体方面在临床和微生物学上均有效。

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