Lee Yoonhee, Oh Yoonseok, Ahn Seok-Yong, Park Hwa-Young, Choi Eung Ho
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Ann Dermatol. 2011 Aug;23(3):352-6. doi: 10.5021/ad.2011.23.3.352. Epub 2011 Aug 6.
Atrophoderma of Pasini and Pierini is a form of dermal atrophy that manifests as either single or multiple, sharply demarcated, hyperpigmented, non-indurated patches. These patches are marked by a slight depression of the skin, with an abrupt edge (i.e., the "cliff-drop" borders), usually located on the backs of adolescents or young adults. The pathophysiology of the disease is unknown, but some authors have suggested a role of Borrelia burgdorferi infection. A 35-year-old woman visited our department because of asymptomatic, hypopigmented, depressed patches on her chest and back lasting for three months. Laboratory evaluations were normal, except for positive serum antibodies to Borrelia burgdorferi. Histologic examination revealed a significantly decreased thickness of the dermis. The patient underwent treatment with oral doxycycline 200 mg/day for six weeks, after which the depth of depression was improved. Herein, we report a case of atrophoderma of Pasini and Pierini, associated with Borrelia burgdorferi infection, successfully treated with oral doxycycline.
帕西尼和皮耶里尼皮肤萎缩症是一种皮肤萎缩形式，表现为单个或多个边界清晰、色素沉着、非硬结性斑块。这些斑块的特点是皮肤有轻微凹陷，边缘陡峭（即“悬崖状”边界），通常位于青少年或年轻人的背部。该病的病理生理学尚不清楚，但一些作者认为伯氏疏螺旋体感染起了一定作用。一名35岁女性因胸部和背部出现无症状、色素减退、凹陷性斑块三个月前来我院就诊。实验室检查除血清伯氏疏螺旋体抗体阳性外均正常。组织学检查显示真皮厚度明显变薄。患者接受了为期六周的口服多西环素200毫克/天治疗，之后凹陷深度有所改善。在此，我们报告一例与伯氏疏螺旋体感染相关的帕西尼和皮耶里尼皮肤萎缩症病例，经口服多西环素成功治愈。
