Lisch W, Seitz B
Augenärztliche Privatpraxis Hanau, Kurt-Blaum-Platz 8, 63450, Hanau, Deutschland.
Ophthalmologe. 2011 Sep;108(9):883-96; quiz 897. doi: 10.1007/s00347-011-2388-8.
The Cornea Society founded an international committee of 17 corneal experts from the USA, Asia and Europe in 2005. The goal of this group was to develop a new international classification of corneal dystrophies (CD) based on modern clinical, histological and genetic knowledge. Both authors are members of this committee. The elaboration of the classification included the correction of many misinterpretations with regard to the different forms of CD which were published in the past literature. In spite of important results concerning the genetic locus and identification of genes and mutations, corneal dystrophies are typically classified with respect to the level of the cornea that is involved. An accurate and up-to-date template for each form of the 25 CDs was created that included the current clinical, histological and genetic information. To indicate the level of evidence supporting the existence of a given dystrophy, the CDs are divided into four different categories. The new international classification of CDs was published in English, Spanish and German as a 40 page supplement with 64 figures, mostly in color. A more detailed description of genetic mutations is included in the appendix.
角膜学会于2005年成立了一个由来自美国、亚洲和欧洲的17位角膜专家组成的国际委员会。该小组的目标是基于现代临床、组织学和遗传学知识制定一种新的国际角膜营养不良（CD）分类法。两位作者均为该委员会成员。分类法的制定包括纠正过去文献中发表的关于不同形式CD的许多误解。尽管在基因座以及基因和突变的鉴定方面取得了重要成果，但角膜营养不良通常根据受累角膜的层次进行分类。为25种CD的每种形式创建了一个准确且最新的模板，其中包括当前的临床、组织学和遗传学信息。为了表明支持特定营养不良存在的证据水平，CD被分为四个不同类别。CD的新国际分类法以英文、西班牙文和德文出版，作为一份40页的增刊，配有64幅插图，大多为彩色。附录中包含了更详细的基因突变描述。
