华蟾素注射液对不同体质荷瘤大鼠肿瘤生长的影响

[Effect of cinobufacini injection on the tumor growth of tumor bearing rats of different constitutions].

作者信息

Wang Shuang-shuang, Zhai Xiao-feng, Li Bai

机构信息

Department of Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Aug;31(8):1101-3.

PMID:21910344

Abstract

OBJECTIVE

To observe effects of cold- and hot-property herbs and effects of hot and cold constitutions on the tumor growth of tumor bearing rats, and to observe the effect of Cinobufacini Injection (CI) on the tumor growth of tumor bearing rats of different constitutions.

METHODS

Eighty healthy male Wistar rats were randomly divided into eight groups, i.e., the tumor bearing control group, the tumor bearing heat syndrome group, the tumor bearing cold syndrome group, the heat syndrome tumor bearing group, the cold syndrome tumor bearing group, the tumor bearing CI group, the heat syndrome tumor bearing CI group, and the cold syndrome tumor bearing CI group, respectively. The weight and volume of rats' subcutaneous tumor were measured 14 days after tumor inoculation.

RESULTS

The weight and volume of tumor in the heat syndrome tumor bearing CI group [(3.55 +/- 1.12) g, (2864.44 +/- 1430.51) mm3] and the tumor bearing CI group [(4.29 +/- 1.14) g, (3397.19 +/- 1701.13) mm3] were significantly lower than those of the tumor bearing control group [(6.01 +/- 2.45) g, (6218.91 +/- 3837.64) mm3] and the cold syndrome tumor bearing CI group [(6.90 +/- 1.57) g, (6168.42 +/- 2457.03) mm3], showing statistical difference (P<0.05). There was insignificant difference among other groups.

CONCLUSIONS

CI showed better tumor inhibition effects on tumor bearing rats of heat syndrome constitution, which indicated CI was of cold property. It might be possibly used in tumor bearing rats of heat syndrome constitution.

摘要

目的

观察寒热属性药物及寒热体质对荷瘤大鼠肿瘤生长的影响，以及华蟾素注射液（CI）对不同体质荷瘤大鼠肿瘤生长的影响。

方法

将80只健康雄性Wistar大鼠随机分为8组，即荷瘤对照组、荷瘤热证组、荷瘤寒证组、热证荷瘤组、寒证荷瘤组、荷瘤CI组、热证荷瘤CI组、寒证荷瘤CI组。接种肿瘤14天后测量大鼠皮下肿瘤的重量和体积。

结果

热证荷瘤CI组肿瘤重量和体积[（3.55±1.12）g，（2864.44±1430.51）mm³]及荷瘤CI组肿瘤重量和体积[（4.29±1.14）g，（3397.19±1701.13）mm³]均显著低于荷瘤对照组[（6.01±2.45）g，（6218.91±3837.64）mm³]及寒证荷瘤CI组[（6.90±1.57）g，（6168.42±2457.03）mm³]，差异有统计学意义（P<0.05）。其他组间差异无统计学意义。