Protasov A D, Zhestkov A V, Lavrenteva N E, Kostinov M P, Ryzhkov A A
Zh Mikrobiol Epidemiol Immunobiol. 2011 Jul-Aug(4):80-4.
Determination of the effect of complex vaccination with Pneumo-23, Hiberix, Grippol plus on sputum bacterial content 6 months after the vaccination of patients with chronic obstructive pulmonary disease (COPD) compared with unvaccinated patients.
Bacteriological analysis of sputum obtained for 6 months from 80 patients with COPD was carried out. The first group of 31 patients with COPD was immunized simultaneously with Pneumo-23, Hiberix, Grippol plus (mean age--59.25 +/- 1.12). The second group consisted of 49 unvaccinated patients with COPD (mean age--57.16 +/- 0.98). Classical microbiological method was used in the study.
6 months after the complex vaccination a significant decrease to 35.48 +/- 8.59% of vaccinated patients, that expectorate sputum with Streptococcus pneumoniae, compared with 80.65 +/- 7.1% in unvaccinated patients with COPD was observed.
A combined vaccination against pneumococcal, haemophilus type b infection and influenza carried out with a prophylactic and therapeutic goal is recommended for patients with COPD as a part of the treatment and prophylaxis complex measures.
与未接种疫苗的慢性阻塞性肺疾病（COPD）患者相比，确定肺炎球菌多糖疫苗23价（Pneumo-23）、b型流感嗜血杆菌结合疫苗（Hiberix）、流感病毒裂解疫苗（Grippol plus）联合接种对COPD患者接种疫苗6个月后痰液细菌含量的影响。
对80例COPD患者6个月内获取的痰液进行细菌学分析。第一组31例COPD患者同时接种Pneumo-23、Hiberix、Grippol plus（平均年龄——59.25±1.12）。第二组由49例未接种疫苗的COPD患者组成（平均年龄——57.16±0.98）。研究采用经典微生物学方法。
联合接种疫苗6个月后，接种疫苗的患者中咳出肺炎链球菌痰液的比例显著下降至35.48±8.59%，而未接种疫苗的COPD患者这一比例为80.65±7.1%。
建议对COPD患者进行针对肺炎球菌、b型流感嗜血杆菌感染和流感的联合接种，作为治疗和预防综合措施的一部分，以达到预防和治疗目的。
