[尘肺病易感性与肿瘤坏死因子-α 308和238位点多态性的荟萃分析]

[A meta-analysis of susceptibility to pneumoconiosis and polymorphism of tumor necrosis factor-α 308 and 238 locus].

作者信息

Li Ju, Hao Chang-fu, Yao Wu, Yun Yu-xia, Gao Bin, Wang Yong-xing

机构信息

Department of Occupational Health Sciences, Zhengzhou University, Zhengzhou 450001, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jun;45(6):547-52.

PMID:21914340

Abstract

OBJECTIVE

To explore the relationship between the polymorphism of TNF-α gene 308, 238 locus and the susceptibility to pneumoconiosis.

METHODS

Eighteen published case-control studies about TNF-α gene 308, 238 locus polymorphism and pneumoconiosis susceptibility were searched out from sino-foreign databases from January 1994 to December 2010. Meta-analysis was applied on the published research to calculate the pooled OR value (95%CI) and stratified analyze the types and species of pneumoconiosis.

RESULTS

Eleven of the published research articles were selected into the analysis, including 10 research focusing on TNF-α gene 308 locus, with 1408 cases and 1639 controls in total. The meta-analysis showed that comparing with Gln/Gln carriers, Arg/Arg, Arg/Gln, Gln/Arg + Arg/Arg carriers were 1.89-fold (95%CI: 1.10 - 3.24), 1.53-fold (95%CI: 1.25 - 1.87), and 1.56-fold (95%CI: 1.28 - 1.90) more susceptible to pneumoconiosis, respectively. The stratified analysis showed that among coal workers, the TNF-α gene 308 locus Arg/Arg, Arg/Gln, Gln/Arg + Arg/Arg carriers were separately 2.29-fold (95%CI: 1.22 - 4.29), 1.56-fold (95%CI: 1.20 - 2.03), 1.64-fold (95%CI: 1.28 - 2.11) more susceptible to pneumoconiosis than Gln/Gln carriers; and among Asian people, the TNF-α gene 308 locus Gln/Arg, Gln/Arg + Arg/Arg carriers were separately 1.58-fold (95%CI: 1.28 - 1.95) and 1.57-fold (95%CI: 1.28 - 1.94) more susceptible to pneumoconiosis than the Gln/Gln carriers. Four case-control research focus on the study of TNF-α gene 238 locus, including 391 cases and 391 controls in total. The analysis showed that comparing with the non-carriers, TNF-α gene 238 locus Arg/Arg, Arg/Gln, Gln/Arg + Arg/Arg carriers were 6.03-fold (95%CI: 1.35 - 26.97), 1.87-fold (95%CI: 1.07 - 3.30) and 2.36-fold (95%CI: 1.37 - 4.07) more susceptible to pneumoconiosis.

CONCLUSION

TNF-α gene 308, 238 locus Arg/Arg, Gln/Arg, Gln/Arg + Arg/Arg carriers are more susceptible to pneumoconiosis.

摘要

目的

探讨肿瘤坏死因子-α（TNF-α）基因308、238位点多态性与尘肺病易感性的关系。

方法

检索1994年1月至2010年12月中外数据库中关于TNF-α基因308、238位点多态性与尘肺病易感性的18篇病例对照研究。对纳入研究进行Meta分析，计算合并比值比（OR）值（95%可信区间），并对尘肺病类型及病种进行分层分析。

结果

共纳入11篇文献进行分析，其中10篇研究聚焦于TNF-α基因308位点，共1408例病例和1639例对照。Meta分析结果显示，与Gln/Gln基因型携带者相比，Arg/Arg、Arg/Gln、Gln/Arg + Arg/Arg基因型携带者患尘肺病的风险分别高1.89倍（95%CI：1.10 - 3.24）、1.53倍（95%CI：1.25 - 1.87）和1.56倍（95%CI：1.28 - 1.90）。分层分析显示，在煤工尘肺患者中，TNF-α基因308位点Arg/Arg、Arg/Gln、Gln/Arg + Arg/Arg基因型携带者患尘肺病的风险分别比Gln/Gln基因型携带者高2.29倍（95%CI：1.22 - 4.29）、1.56倍（95%CI：1.20 - 2.03）、1.64倍（95%CI：1.28 - 2.11）；在亚洲人群中，TNF-α基因308位点Gln/Arg、Gln/Arg + Arg/Arg基因型携带者患尘肺病的风险分别比Gln/Gln基因型携带者高1.58倍（95%CI：1.28 - 1.95）和1.57倍（95%CI：1.28 - 1.94）。4篇病例对照研究聚焦于TNF-α基因238位点，共391例病例和391例对照。分析结果显示，与非携带者相比，TNF-α基因238位点Arg/Arg、Arg/Gln、Gln/Arg + Arg/Arg基因型携带者患尘肺病的风险分别高6.03倍（95%CI：1.35 - 26.97）、1.87倍（95%CI：1.07 - 3.30）和2.36倍（95%CI：1.37 - 4.07）。