Callard R E, Turner M W
Department of Immunology, Institute of Child Health, London, UK.
Immunol Today. 1990 Jun;11(6):200-3. doi: 10.1016/0167-5699(90)90082-k.
Cytokines exert control over many aspects of immunoglobulin regulation, including isotype switching. But is the same mechanism used in subclass regulation in mice and humans? Robin Callard and Malcolm Turner think not, and here caution against the wholesale application of murine studies to humans.
细胞因子对免疫球蛋白调节的许多方面都有控制作用，包括同种型转换。但小鼠和人类在亚类调节中使用的是相同机制吗？罗宾·卡勒德和马尔科姆·特纳认为并非如此，在此他们提醒不要将小鼠研究结果全盘应用于人类。
