[Usefulness of oral rehydration solution for hydration in cancer chemotherapy: toward the application of outpatient chemotherapy with high-dose Cisplatin therapy-].

Currently, outpatient cancer chemotherapy has been commonly performed in Japan. However, chemotherapies using cisplatin( CDDP)are seldom given to outpatients because they require vigorous hydration to reduce CDDP-induced nephrotoxicity. In this study, we investigated the protective effect of oral rehydration solution(ORS)against CDDP-induced nephrotoxicity, and found that ORS could be beneficial to outpatients for oral hydration. Male F344 rats were intraperitoneally injected with 2mg/kg once a week for 9 weeks. Sixty mL/kg/day of water or ORS were orally administered for hydration for 3 days after the CDDP-injection day, and changes in renal functions were evaluated. After the last CDDP injection, rats were sacrificed for histopathological evaluation of the kidney. Evaluations of serum creatinine, urea nitrogen, creatinine clearance and FENa revealed that nephrotoxicity was prevented more effectively by oral hydration using ORS than by using normal water. In addition, histopathological evaluation showed that hydration using ORS was more effective for reducing renal tubular damage than normal water. These results suggest that ORS is more effective for the prevention of CDDP-induced nephrotoxicity than normal water. Therefore, ORS may be a useful tool to help promote outpatient cancer chemotherapy using CDDP.