Department of Respiratory Medicine, Churchill Hospital, Oxford, UK.
Colorectal Dis. 2012 Jul;14(7):844-7. doi: 10.1111/j.1463-1318.2011.02828.x.
Colorectal cancer is common and a leading cause of cancer death. Faecal occult blood screening has been shown to reduce mortality. The aim of this study was to identify patients in Gloucestershire with a new diagnosis of colorectal cancer who had previously been screened via the Bowel Cancer Screening Programme (BCSP).
Between 2006 and 2009, 1030 patients were diagnosed with colorectal cancer. Of these 237 (23%) had been invited to be screened via the BCSP. Their clinical notes were analysed.
Fifty-seven (24%) of the 237 patients had previously had a negative faecal occult blood result. Thirty-three (14%) had their cancer discovered as part of the BCSP. Seventy (30%) had already been diagnosed with colorectal cancer prior to invitation, 62 (26%) did not respond to the invitation, nine (4%) were registered outside Gloucestershire and had therefore not been invited, and three (3%) had died before the invitation. Of the 57 patients with a negative faecal occult blood test, 47 (83%) had colorectal cancer staged Dukes B or C, and 34 (60%) had a rectal or sigmoid cancer.
Patients will present with colorectal cancer despite having been invited to participate in the BCSP, with many having received a negative faecal occult blood test. This could be considered a high false negative rate.
结直肠癌是一种常见的癌症，也是癌症死亡的主要原因之一。粪便潜血筛查已被证明可以降低死亡率。本研究的目的是确定格洛斯特郡新诊断为结直肠癌的患者中，有多少人曾通过肠癌筛查计划（BCSP）接受过筛查。
在 2006 年至 2009 年间，有 1030 名患者被诊断患有结直肠癌。其中 237 名（23%）被邀请通过 BCSP 进行筛查。分析了他们的临床记录。
237 名患者中，57 名（24%）之前的粪便潜血检测结果为阴性。33 名（14%）的癌症是在 BCSP 中发现的。70 名（30%）在邀请前已被诊断为结直肠癌，62 名（26%）未对邀请做出回应，9 名（4%）在格洛斯特郡以外的地方注册，因此未被邀请，3 名（3%）在邀请前已死亡。在 57 名粪便潜血检测阴性的患者中，47 名（83%）的结直肠癌分期为 Dukes B 或 C，34 名（60%）患有直肠或乙状结肠癌。
尽管患者被邀请参加 BCSP，但仍会出现结直肠癌，其中许多人接受了粪便潜血检测，且检测结果为阴性。这可以被认为是一个高假阴性率。
