免疫化学粪便潜血试验结果为假阴性的结直肠癌特征

Characteristics of colorectal cancer with false negative result on immunochemical faecal occult blood test.

作者信息

Nakama H, Kamijo N, Fujimori K, Horiuchi A, Fattah A S, Zhang B

机构信息

Department of Public Health, Shinshu University School of Medicine, Japan.

出版信息

J Med Screen. 1996;3(3):115-8. doi: 10.1177/096914139600300302.

DOI:10.1177/096914139600300302

PMID:8946304

Abstract

OBJECTIVES

A comparative study was carried out to clarify the clinicopathological features of colorectal cancer diagnosed after a false negative result on the immunochemical faecal occult blood test.

METHODS

236 patients with colorectal cancer were studied: 48 patients with negative results and 188 patients with positive results with the faecal occult blood test. The two groups were compared according to their age and sex and by the site, size, macroscopic type, Dukes's classification, and histological type of their cancer lesions. Additionally, the above factors were investigated prospectively and compared in 40 cases of colorectal cancer cases diagnosed as false negative and in matched cases diagnosed as true positive in cancer screening by the immunochemical faecal occult blood test.

RESULTS

In both the hospital based case-control study and the screening programme based nested case-control study the prevalence of rectal cancers was higher in the false negative group than in the true positive group (P = 0.02, P = 0.03), but there were no differences between the two groups for any other factors.

CONCLUSION

These results suggest that the immunochemical faecal occult blood test is unsuitable for the diagnosis of rectal cancer.

摘要

目的

开展一项比较研究以阐明在免疫化学粪便潜血试验出现假阴性结果后确诊的结直肠癌的临床病理特征。

方法

对236例结直肠癌患者进行研究：48例粪便潜血试验结果为阴性，188例结果为阳性。根据年龄、性别以及癌症病变的部位、大小、大体类型、Dukes分期和组织学类型对两组进行比较。此外，对40例在免疫化学粪便潜血试验癌症筛查中被诊断为假阴性的结直肠癌病例以及匹配的被诊断为真阳性的病例，前瞻性地调查上述因素并进行比较。