磷酸化的H2Ax并非DNA双链断裂的明确标志物。 - Suppr

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Phosphorylated H2Ax is not an unambiguous marker for DNA double-strand breaks.

作者信息

Cleaver James E, Feeney Luzviminda, Revet Ingrid

出版信息

Cell Cycle. 2011 Oct 1;10(19):3223-4. doi: 10.4161/cc.10.19.17448.

DOI:10.4161/cc.10.19.17448

PMID:21921674

Abstract

摘要

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Phosphorylated H2Ax is not an unambiguous marker for DNA double-strand breaks.

作者信息

Cleaver James E, Feeney Luzviminda, Revet Ingrid

出版信息

Cell Cycle. 2011 Oct 1;10(19):3223-4. doi: 10.4161/cc.10.19.17448.

DOI:10.4161/cc.10.19.17448

PMID:21921674

Abstract

摘要

相似文献

Phosphorylated H2Ax is not an unambiguous marker for DNA double-strand breaks.

Cell Cycle. 2011 Oct 1;10(19):3223-4. doi: 10.4161/cc.10.19.17448.

[gamma H2AX in the recognition of DNA double-strand breaks].

Postepy Hig Med Dosw (Online). 2009 Feb 27;63:92-8.

Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents.

Cytometry A. 2007 Sep;71(9):648-61. doi: 10.1002/cyto.a.20426.

Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis.

Cytometry A. 2006 Apr;69(4):212-21. doi: 10.1002/cyto.a.20241.

Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis.

Cytometry A. 2005 Nov;68(1):1-9. doi: 10.1002/cyto.a.20186.

Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1.

Biochem Biophys Res Commun. 2009 Mar 20;380(4):752-7. doi: 10.1016/j.bbrc.2009.01.109. Epub 2009 Jan 23.

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.

BMC Mol Biol. 2010 Mar 6;11:18. doi: 10.1186/1471-2199-11-18.

DNA double strand break repair: zooming in on the focus.

Cell Cycle. 2009 Dec;8(23):3813-5. Epub 2009 Dec 1.

Neighborly DISCourse: DNA double strand breaks silence transcription.

Cell Cycle. 2010 Sep 15;9(18):3635-6. doi: 10.4161/cc.9.18.13171. Epub 2010 Sep 28.

ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis.

Cell Prolif. 2006 Feb;39(1):49-60. doi: 10.1111/j.1365-2184.2006.00364.x.

引用本文的文献

Radiation-Induced Gamma-H2AX Foci Staining and Analysis.

Methods Mol Biol. 2025;2933:25-29. doi: 10.1007/978-1-0716-4574-1_4.

Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells.

PLoS Biol. 2025 Feb 21;23(2):e3003034. doi: 10.1371/journal.pbio.3003034. eCollection 2025 Feb.

Cosmic Whirl: Navigating the Comet Trail in DNA: H2AX Phosphorylation and the Enigma of Uncertain Significance Variants.

Genes (Basel). 2024 Jun 1;15(6):724. doi: 10.3390/genes15060724.

DNA Double Strand Break and Response Fluorescent Assays: Choices and Interpretation.

Int J Mol Sci. 2024 Feb 13;25(4):2227. doi: 10.3390/ijms25042227.

Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes.

Geroscience. 2024 Apr;46(2):1861-1879. doi: 10.1007/s11357-023-00933-z. Epub 2023 Sep 26.

Imaging the cellular response to an antigen tagged interstrand crosslinking agent.

DNA Repair (Amst). 2023 Aug;128:103525. doi: 10.1016/j.dnarep.2023.103525. Epub 2023 Jun 9.

SPRTN-dependent DPC degradation precedes repair of damaged DNA: a proof of concept revealed by the STAR assay.

Nucleic Acids Res. 2023 Apr 11;51(6):e35. doi: 10.1093/nar/gkad022.

Persistent DNA damage underlies tubular cell polyploidization and progression to chronic kidney disease in kidneys deficient in the DNA repair protein FAN1.

Kidney Int. 2022 Nov;102(5):1042-1056. doi: 10.1016/j.kint.2022.07.003. Epub 2022 Aug 2.

Unraveling the Molecular Impact of Sperm DNA Damage on Human Reproduction.

Adv Exp Med Biol. 2022;1358:77-113. doi: 10.1007/978-3-030-89340-8_5.

GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation.

Cells. 2022 Mar 9;11(6):935. doi: 10.3390/cells11060935.