大理石掩埋作为强迫和/或焦虑动物模型的充分性的药理学评估。
Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety.
作者信息
Jimenez-Gomez Corina, Osentoski Andrew, Woods James H
机构信息
University of Michigan, Michigan, USA.
出版信息
Behav Pharmacol. 2011 Oct;22(7):711-3. doi: 10.1097/FBP.0b013e32834afebe.
Abstract
Marble-burying behavior in rodents has been used commonly as an animal model of compulsive and/or anxiety behavior. The purpose of this study was to further assess the adequacy of marble burying as a preclinical animal model of compulsive behaviors using pharmacological tools. In particular, we were interested in whether dopamine D2/D3 agonists (e.g. pramipexole) known to produce compulsive behaviors in humans would increase marble burying. The effects of pramipexole on marble-burying behavior and locomotor activity were compared with those of the following: diazepam, a drug known to decrease marble burying; D-amphetamine, a stimulant that increases locomotor activity; and methyl β-carboline-3-carboxylate, a β-carboline previously shown to produce anxiogenic effects in rodents. All drugs produced dose-dependent decreases in marble burying, which were not always related to the locomotor effects of these drugs. The inability of pramipexole and methyl β-carboline-3-carboxylate to increase marble burying questions the validity of this assay as an adequate animal model of compulsive and/or anxiety behavior.
摘要
啮齿动物的埋大理石行为通常被用作强迫和/或焦虑行为的动物模型。本研究的目的是使用药理学工具进一步评估埋大理石行为作为强迫行为临床前动物模型的充分性。特别地，我们感兴趣的是，已知会在人类中产生强迫行为的多巴胺D2/D3激动剂（如普拉克索）是否会增加埋大理石行为。将普拉克索对埋大理石行为和运动活动的影响与以下药物的影响进行了比较：地西泮，一种已知会减少埋大理石行为的药物；D-苯丙胺，一种增加运动活动的兴奋剂；以及甲基β-咔啉-3-羧酸盐，一种先前已证明会在啮齿动物中产生致焦虑作用的β-咔啉。所有药物均使埋大理石行为呈剂量依赖性减少，这并不总是与这些药物的运动效应相关。普拉克索和甲基β-咔啉-3-羧酸盐无法增加埋大理石行为，这对该试验作为强迫和/或焦虑行为的充分动物模型的有效性提出了质疑。
相似文献
1
Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety.大理石掩埋作为强迫和/或焦虑动物模型的充分性的药理学评估。
Behav Pharmacol. 2011 Oct;22(7):711-3. doi: 10.1097/FBP.0b013e32834afebe.
2
A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants.小鼠大理石埋藏-运动活动联合测试：一种对不同类别抗焦虑药和抗抑郁药敏感的实用筛选测试。
Eur J Pharmacol. 2006 Oct 10;547(1-3):106-15. doi: 10.1016/j.ejphar.2006.07.015. Epub 2006 Jul 25.
3
Marble burying as compulsive behaviors in male and female mice.大理石掩埋行为作为雄性和雌性小鼠的强迫行为
Acta Neurobiol Exp (Wars). 2017;77(3):254-260.
4
A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: Mapping the way forward.对大理石掩埋作为焦虑和强迫症临床前筛选范式的批判性探究：为前进铺平道路。
Cogn Affect Behav Neurosci. 2019 Feb;19(1):1-39. doi: 10.3758/s13415-018-00653-4.
5
The antipsychotic trifluoperazine reduces marble-burying behavior in mice via D and 5-HT receptors: Implications for obsessive-compulsive disorder.抗精神病药三氟拉嗪通过 D 和 5-HT 受体减少小鼠的埋珠行为：对强迫症的影响。
Pharmacol Biochem Behav. 2018 Feb;165:9-13. doi: 10.1016/j.pbb.2017.12.006. Epub 2017 Dec 19.
6
Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms.阿立哌唑通过不依赖5-羟色胺（5-HT）1A受体的机制抑制埋大理石行为。
Eur J Pharmacol. 2008 Sep 11;592(1-3):103-8. doi: 10.1016/j.ejphar.2008.06.100. Epub 2008 Jul 4.
7
Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system.心境稳定剂对小鼠埋珠行为的影响：涉及 GABA 能系统。
Psychopharmacology (Berl). 2013 Mar;226(2):295-305. doi: 10.1007/s00213-012-2904-9. Epub 2012 Oct 21.
8
Marble-burying behavior test as a murine model of compulsive-like behavior.大理石掩埋行为测试作为一种强迫样行为的小鼠模型。
J Pharmacol Toxicol Methods. 2020 Mar-Apr;102:106676. doi: 10.1016/j.vascn.2020.106676. Epub 2020 Jan 16.
9
Decreases in nestlet shredding of mice by serotonin uptake inhibitors: comparison with marble burying.血清素摄取抑制剂对小鼠筑巢材料撕碎行为的减少作用：与大理石掩埋行为的比较。
Life Sci. 2006 Mar 20;78(17):1933-9. doi: 10.1016/j.lfs.2005.08.002. Epub 2005 Sep 22.
10
Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.哌罗匹隆是一种新型抗精神病药物，通过5-HT1A受体抑制小鼠的埋大理石行为：对强迫症的启示。
J Pharmacol Sci. 2005 Oct;99(2):154-9. doi: 10.1254/jphs.fp0050144. Epub 2005 Oct 6.
引用本文的文献
1
Personality-based intergenerational effects of prenatal THC exposure in an inherited mouse model of social dominance and submissiveness.在社会主导和顺从的遗传小鼠模型中，产前暴露于四氢大麻酚的基于个性的代际效应。
Sci Rep. 2025 Aug 20;15(1):30624. doi: 10.1038/s41598-025-15528-1.
2
Premorbid characteristics of the SAPAP3 mouse model of obsessive-compulsive disorder: behavior, neuroplasticity, and psilocybin treatment.强迫症的SAPAP3小鼠模型的病前特征：行为、神经可塑性和裸盖菇素治疗。
Int J Neuropsychopharmacol. 2025 May 9;28(5). doi: 10.1093/ijnp/pyaf022.
3
Entrance-sealing behavior in the home cage: a defensive response to potential threats linked to the serotonergic system and manifestation of repetitive/stereotypic behavior in mice.笼内入口封堵行为：小鼠对与血清素能系统相关的潜在威胁的防御反应及重复/刻板行为的表现
Front Behav Neurosci. 2024 Jan 5;17:1289520. doi: 10.3389/fnbeh.2023.1289520. eCollection 2023.
4
Characterization of Behavioral Phenotypes in Heterozygous DAT Rat Based on Pedigree.基于谱系的杂合 DAT 大鼠行为表型特征分析
Biomedicines. 2023 Sep 18;11(9):2565. doi: 10.3390/biomedicines11092565.
5
Maternal separation and its developmental consequences on anxiety and parvalbumin interneurons in the amygdala.母鼠分离及其对杏仁核中焦虑和小白蛋白中间神经元的发育影响。
J Neural Transm (Vienna). 2023 Sep;130(9):1167-1175. doi: 10.1007/s00702-023-02657-y. Epub 2023 Jun 9.
6
3-Methyladenine ameliorates surgery-induced anxiety-like behaviors in aged mice by inhibiting autophagy-induced excessive oxidative stress.3-甲基腺嘌呤通过抑制自噬诱导的过度氧化应激改善老年小鼠手术引起的焦虑样行为。
Metab Brain Dis. 2023 Aug;38(6):1913-1923. doi: 10.1007/s11011-023-01217-3. Epub 2023 Apr 25.
7
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery.新冠病毒（SARS-CoV-2）感染仓鼠和人类后，在康复后会导致持久且独特的全身性干扰。
Sci Transl Med. 2022 Sep 28;14(664):eabq3059. doi: 10.1126/scitranslmed.abq3059.
8
Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams-Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression.维拉帕米与姜黄素联合治疗通过调节丝裂原活化蛋白激酶（MAPK）信号通路和小胶质细胞过表达减轻威廉姆斯-伯伦综合征小鼠的行为改变。
Front Pharmacol. 2021 Aug 3;12:670785. doi: 10.3389/fphar.2021.670785. eCollection 2021.
9
Fine-Tuning the PI3K/Akt Signaling Pathway Intensity by Sex and Genotype-Load: Sex-Dependent Homozygotic Threshold for Somatic Growth but Feminization of Anxious Phenotype in Middle-Aged PDK1 K465E Knock-In and Heterozygous Mice.通过性别和基因型负荷微调PI3K/Akt信号通路强度：体细胞生长的性别依赖性纯合阈值以及中年PDK1 K465E基因敲入和杂合小鼠焦虑表型的雌性化。
Biomedicines. 2021 Jun 28;9(7):747. doi: 10.3390/biomedicines9070747.
10
Repeated exposure to JWH-018 induces adaptive changes in the mesolimbic and mesocortical dopaminergic pathways, glial cells alterations, and behavioural correlates.反复暴露于 JWH-018 会导致中脑边缘和中脑皮质多巴胺能通路、神经胶质细胞改变以及行为相关性的适应性变化。
Br J Pharmacol. 2021 Sep;178(17):3476-3497. doi: 10.1111/bph.15494. Epub 2021 Jun 29.
本文引用的文献
1
Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients.帕金森病中的冲动控制障碍：一项对3090例患者的横断面研究。
Arch Neurol. 2010 May;67(5):589-95. doi: 10.1001/archneurol.2010.65.
2
A case of compulsive behaviors observed in a restless legs syndrome patient treated with a dopamine agonist.1例使用多巴胺激动剂治疗的不宁腿综合征患者出现强迫行为的病例。
Sleep. 2009 May;32(5):587-8. doi: 10.1093/sleep/32.5.587.
3
Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety.大理石掩埋反映的是一种重复性和持续性的行为，而非新奇诱导的焦虑。
Psychopharmacology (Berl). 2009 Jun;204(2):361-73. doi: 10.1007/s00213-009-1466-y. Epub 2009 Feb 3.
4
Increased marble-burying behavior in ethanol-withdrawal state: modulation by gonadotropin-releasing hormone agonist.乙醇戒断状态下大理石掩埋行为增加：促性腺激素释放激素激动剂的调节作用
Eur J Pharmacol. 2008 Jun 10;587(1-3):175-80. doi: 10.1016/j.ejphar.2008.03.035. Epub 2008 Apr 1.
5
Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice.抗精神病药物和参考单胺能配体对小鼠埋大理石行为的影响。
Behav Pharmacol. 2008 Mar;19(2):145-52. doi: 10.1097/FBP.0b013e3282f62cb2.
6
Association of dopamine agonist use with impulse control disorders in Parkinson disease.帕金森病中多巴胺激动剂的使用与冲动控制障碍的关联
Arch Neurol. 2006 Jul;63(7):969-73. doi: 10.1001/archneur.63.7.969.
7
Animal models of obsessive-compulsive disorder: rationale to understanding psychobiology and pharmacology.强迫症的动物模型：理解心理生物学和药理学的理论基础
Psychiatr Clin North Am. 2006 Jun;29(2):371-90. doi: 10.1016/j.psc.2006.02.007.
8
Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice.根据对小鼠大理石埋藏行为和游泳诱导梳理行为的影响，可将强安定药与弱安定药区分开来。
Eur J Pharmacol. 1986 Jul 31;126(3):223-9. doi: 10.1016/0014-2999(86)90051-8.
9
Evaluation of marble-burying behavior as a model of anxiety.作为焦虑模型的大理石掩埋行为评估
Pharmacol Biochem Behav. 1991 Jan;38(1):63-7. doi: 10.1016/0091-3057(91)90590-x.
10
Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents.5-羟色胺摄取抑制剂、激动剂及拮抗剂对小鼠掩埋无害物体行为的影响；一种潜在的抗焦虑药物测试方法
Br J Pharmacol. 1991 Sep;104(1):105-12. doi: 10.1111/j.1476-5381.1991.tb12392.x.
Zotero 插件