Jimenez-Gomez Corina, Osentoski Andrew, Woods James H
University of Michigan, Michigan, USA.
Behav Pharmacol. 2011 Oct;22(7):711-3. doi: 10.1097/FBP.0b013e32834afebe.
Marble-burying behavior in rodents has been used commonly as an animal model of compulsive and/or anxiety behavior. The purpose of this study was to further assess the adequacy of marble burying as a preclinical animal model of compulsive behaviors using pharmacological tools. In particular, we were interested in whether dopamine D2/D3 agonists (e.g. pramipexole) known to produce compulsive behaviors in humans would increase marble burying. The effects of pramipexole on marble-burying behavior and locomotor activity were compared with those of the following: diazepam, a drug known to decrease marble burying; D-amphetamine, a stimulant that increases locomotor activity; and methyl β-carboline-3-carboxylate, a β-carboline previously shown to produce anxiogenic effects in rodents. All drugs produced dose-dependent decreases in marble burying, which were not always related to the locomotor effects of these drugs. The inability of pramipexole and methyl β-carboline-3-carboxylate to increase marble burying questions the validity of this assay as an adequate animal model of compulsive and/or anxiety behavior.
啮齿动物的埋大理石行为通常被用作强迫和/或焦虑行为的动物模型。本研究的目的是使用药理学工具进一步评估埋大理石行为作为强迫行为临床前动物模型的充分性。特别地，我们感兴趣的是，已知会在人类中产生强迫行为的多巴胺D2/D3激动剂（如普拉克索）是否会增加埋大理石行为。将普拉克索对埋大理石行为和运动活动的影响与以下药物的影响进行了比较：地西泮，一种已知会减少埋大理石行为的药物；D-苯丙胺，一种增加运动活动的兴奋剂；以及甲基β-咔啉-3-羧酸盐，一种先前已证明会在啮齿动物中产生致焦虑作用的β-咔啉。所有药物均使埋大理石行为呈剂量依赖性减少，这并不总是与这些药物的运动效应相关。普拉克索和甲基β-咔啉-3-羧酸盐无法增加埋大理石行为，这对该试验作为强迫和/或焦虑行为的充分动物模型的有效性提出了质疑。
